Journal
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 31, Issue 2, Pages 273-280Publisher
CONNECT JOURNALS
Keywords
Oxadiazole; Thiadiazole; Zone of inhibition; Antibacterial; Antifungal
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A series of 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives were synthesized and found to exhibit antimicrobial activity against a broad range of Gram-positive and Gram-negative bacteria as well as fungi.
A series of 1,3,4-oxadiazole clubbed 1,3,4-thiadiazole derivatives were synthesized and assessed in vitro for their activity as antimicrobial agents. The target compounds 2-(5-(substituted aryl)-1, 3, 4-oxadiazol-2-ylthio)-N-(5-(substituted aryl)-1, 3, 4-thiadiazol-2-yl) acetamides (5a-5s) were synthesized using a basic condensation reaction between 5-(substituted aryl)-1,3,4-oxadiazole-2-thiol and 2-chloroN-(5-(substituted aryl)-1,3,4-thiadiazol-2-yl)acetamide in presence of K2CO3 as a scavenging agent and acetone as reaction solvent. The titled compounds synthesized here, exhibited excellent to moderate antimicrobial activity against a broad panel of antibacterial strains of Gram-positive and Gram-negative bacteria and fungi.
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