Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus

To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that modulate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology.

Automated summary

The study identifies SLC6A20 and CXCR6 as potential causal genes that modulate COVID-19 risk by integrating genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues. This integrative approach bridges the gap between correlational and causal studies in human biology.