Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 72, Pages 9128-9131Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc03539h
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Funding
- Independent Research Fund Denmark-Natural Sciences [DFF-7014-00052]
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Research has shown that double-headed nucleotides containing two nucleobases each can form two sets of functional Watson-Crick base pairs when incorporated into dsDNA, behaving as dinucleotides. By preparing three new double-headed nucleic acid monomers, it has been demonstrated that the molecular information of 10 Watson-Crick base pairs can be condensed into highly stable 5-mer DhNA duplexes.
Nucleotide monomers that hold two nucleobases each, i.e. double-headed nucleotides, have been shown to form two sets of functional Watson-Crick base pairs when incorporated into dsDNA, and they hereby behave as dinucleotides. To form the basis for fully modified double-headed nucleic acids (DhNA), we have prepared three new DhNA monomers and can now demonstrate that the molecular information of 10 Watson-Crick base pairs can be condensed to highly stable 5-mer DhNA duplexes.
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