Journal
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
Volume 19, Issue -, Pages 2687-2698Publisher
ELSEVIER
DOI: 10.1016/j.csbj.2021.05.001
Keywords
Microbial co-occurrence networks; Microbial interactions; Network analysis; Trans-kingdom interactions
Funding
- Deutsche Forschungsgemeinschaft (DFG, German 582 Research Foundation) [395357507 -SFB 1371]
- Hanns-Seidel-Stiftung
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The article provides an overview of state-of-the-art methods for inferring intra-kingdom interactions in microbial communities. It discusses common biases encountered in microbial profiles and mitigation strategies, as well as current limitations and the need for further method development.
Microorganisms including bacteria, fungi, viruses, protists and archaea live as communities in complex and contiguous environments. They engage in numerous inter- and intra- kingdom interactions which can be inferred from microbiome profiling data. In particular, network-based approaches have proven helpful in deciphering complex microbial interaction patterns. Here we give an overview of state-of-the-art methods to infer intra-kingdom interactions ranging from simple correlation- to complex conditional dependence-based methods. We highlight common biases encountered in microbial profiles and discuss mitigation strategies employed by different tools and their trade-off with increased computational complexity. Finally, we discuss current limitations that motivate further method development to infer inter-kingdom interactions and to robustly and comprehensively characterize microbial environments in the future. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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