Catalytic three-component dicarbofunctionalization reactions involving radical capture by nickel

The catalytic dicarbofunctionalization of unsaturated pi bonds represents a powerful platform for the rapid construction of complex motifs. Despite remarkable progress, novel and efficient methods for achieving such transformations under milder conditions with chemo-, regio-, and stereoselectivity still remain a significant challenge; thus, their development is highly desirable. Recently, the merging of nickel catalysis with radical chemistry offers a new and benign platform for the catalytic dicarbofunctionalization of unsaturated pi bonds with unprecedented reactivity and selectivity. In this review, we summarize the recent advances in this area by underpinning the catalytic domino transformations involving radical capture by nickel to provide a clear overview of reaction designs and mechanistic scenarios.

Automated summary

The merging of nickel catalysis with radical chemistry has provided a new and benign platform for the catalytic dicarbofunctionalization of unsaturated pi bonds with unprecedented reactivity and selectivity. Recent advances in this area mainly involve catalytic domino transformations and exploration of reaction mechanisms.