4.7 Article

Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

Goran Kokic et al.

Summary: Remdesivir is the only FDA-approved drug for treating COVID-19 patients, working by inhibiting the RNA-dependent RNA polymerase (RdRp) of coronaviruses. It hinders RNA synthesis and impairs proofreading by the viral 3'-exonuclease, leading to a stalled replication process.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

Sebastian Guenther et al.

Summary: The study identified 37 compounds that bind to the SARS-CoV-2 main protease through a high-throughput x-ray crystallographic screen of two repurposing drug libraries. Among these compounds, one peptidomimetic and six nonpeptidic compounds showed antiviral activity in cell-based viral reduction assays at nontoxic concentrations. The identification of two allosteric binding sites presents potential targets for drug development against SARS-CoV-2.

SCIENCE (2021)

Article Multidisciplinary Sciences

A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

Article Multidisciplinary Sciences

U1 snRNP regulates cancer cell migration and invasion in vitro

Jung-Min Oh et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

Zhenming Jin et al.

NATURE (2020)

Article Microbiology

Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients

Philip M. Carlucci et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2020)

News Item Medicine, General & Internal

Covid-19: New coronavirus variant is identified in UK

Jacqui Wise

BMJ-BRITISH MEDICAL JOURNAL (2020)

Article Infectious Diseases

COVID-19: Poor outcomes in patients with zinc deficiency

Dinesh Jothimani et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Review Nutrition & Dietetics

The Role of Zinc in Antiviral Immunity

Scott A. Read et al.

ADVANCES IN NUTRITION (2019)

Review Biochemistry & Molecular Biology

Zinc in Cellular Regulation: The Nature and Significance of Zinc Signals

Wolfgang Maret

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

The emerging role of zinc transporters in cellular homeostasis and cancer

Elizabeth Bafaro et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

Article Agriculture, Multidisciplinary

Zinc lonophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model

Husam Dabbagh-Bazarbachi et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)

Review Biochemistry & Molecular Biology

Inhibitory zinc sites in enzymes

Wolfgang Maret

BIOMETALS (2013)

Article Medicine, Research & Experimental

Zinc lozenges as cure for the common cold - A review and hypothesis

George A. Eby

MEDICAL HYPOTHESES (2010)

Article Biochemistry & Molecular Biology

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

Cheng-Chung Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors

Cheng-Chung Lee et al.

FEBS LETTERS (2007)

Article Biochemistry & Molecular Biology

Zinc coordination environments in proteins determine zinc functions

W Maret

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV

JTA Hsu et al.

FEBS LETTERS (2004)