4.4 Article

Ginsenoside Rh1 attenuates ovalbumin-induced asthma by regulating Th1/Th2 cytokines balance

Journal

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 85, Issue 8, Pages 1809-1817

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/bbb/zbab099

Keywords

allergic asthma; Th1/Th2; ginsenoside Rh1; inflammation; airway hyper-responsiveness

Funding

  1. Zhejiang Provincial Natural Science Foundation of CHINA [Y20H290003]

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The study showed that Rh1 significantly alleviated asthma symptoms in mice, including lung resistance, airway resistance, and inflammation cell count. Furthermore, Rh1 reversed the imbalance of Th1/Th2 cytokines in the mice model.
Ginsenoside Rh1 (Rh1) has anti-inflammatory effects in asthma mice, but the underlying mechanism remains unclear. BALB/c mice were sensitized and challenged with ovalbumin (OVA) to construct asthma model. Mice received Rh1 or tiotropium bromide 0.5 h before OVA challenge. Airway morphology and airway remodeling were assessed by HE staining and Masson's trichrome staining, respectively. Th1/Th2 cytokines in serum or broncho alveolar lavage fluid (BALF) were measured by ELISA kits. Rh1 significantly alleviated the lung resistance and airway resistance, and reduced the number of total inflammation cells, eosinophils, neutrophils, and lymphocytes in BALF of the asthmatic mice. The morphological changes and collagen deposition of airway were also reduced by Rh1 in asthmatic mice. The increase of Eotaxin, IL-4, IL-5, IL-13, and IL-33 and the decrease of IL-12 and IFN-gamma in both BALF and serum of OVA exposed mice were reversed by Rh1. Rh1 attenuates OVA-induced asthma in the mice model by regulating Th1/Th2 cytokines balance. [GRAPHICS] .

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