Journal
EUROPEAN JOURNAL OF CANCER
Volume 153, Issue -, Pages 260-264Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2021.05.006
Keywords
Cancer patients; COVID-19; Vaccine; BNT162b2; Refusal; SARS-CoV-2; Public health
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This study reported on the compliance with COVID-19 vaccination among patients affected by solid tumors, revealing concerns about vaccine-related adverse events, negative interactions with concomitant antitumor therapy, and fear of allergic reactions as common reasons for refusal. Additionally, the refusal rate more than doubled after the suspension of AstraZeneca-AZD1222, indicating the impact of regulatory decisions and media news on vaccination campaigns.
Introduction: Patients with cancer have an increased risk of complications from coronavirus disease 2019 (COVID-19) infection, including death, and thus, they were considered as high-priority subjects for COVID-19 vaccination. We report on the compliance with the COVID-19 vaccine of patients affected by solid tumours. Materials and methods: Patients with cancer afferent to Medical Oncology 1 Unit of Regina Elena National Cancer Institute in Rome were considered eligible for vaccination if they were receiving systemic immunosuppressive antitumor treatment or received it in the last 6 months or having an uncontrolled advanced disease. The Pfizer BNT162b2 vaccine was proposed to all candidates via phone or during a scheduled visit. The reasons for refusal were collected by administrating a 6-item multiple-choice questionnaire. Results: From 1st March to 20th March 2021, of 914 eligible patients, 102 refused vaccination (11.2%, 95% confidence interval [CI] 9.1-13.2). The most frequent (>10%) reasons reported were concerns about vaccine-related adverse events (48. 1%), negative interaction with concomitant antitumor therapy (26.7%), and the fear of allergic reaction (10.7%). The refusal rate (RR) after 15th March (date of AstraZeneca-AZD1222 suspension) was more than doubled compared with the RR observed before (19.7% versus 8.6%, odds ratio [OR] 2.60, 95% CI 1.69-3.99; P < 0.0001). ECOG-PS 2 was associated with higher RR compared with ECOG-PS 0-1 (OR 2.94, 95% CI 1.04-8.34; P Z 0.04). No statistically significant differences in RR according to other clinical characteristics were found. Conclusions: Our experience represents the first worldwide report on the adherence of patients with cancer to COVID-19 vaccination and underlines how regulatory decisions and media news spreading could influence the success of the campaign. (c) 2021 Elsevier Ltd. All rights reserved.
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