Journal
NANOSCALE ADVANCES
Volume 3, Issue 18, Pages 5183-5221Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1na00036e
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Funding
- Fondazione AIRC per la Ricerca sul Cancro [AIRC IG23566]
- SPIN
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Carbon nanomaterials have shown great potential in various fields, especially in biomedicine, due to their unique physical and chemical properties. They have been utilized for imaging, therapy, and drug delivery applications, offering a promising alternative to traditional therapeutic approaches.
Cancer remains one of the main causes of death in the world. Early diagnosis and effective cancer therapies are required to treat this pathology. Traditional therapeutic approaches are limited by lack of specificity and systemic toxicity. In this scenario, nanomaterials could overcome many limitations of conventional approaches by reducing side effects, increasing tumor accumulation and improving the efficacy of drugs. In the past few decades, carbon nanomaterials (i.e., fullerenes, carbon nanotubes, and carbon dots) have attracted significant attention of researchers in various scientific fields including biomedicine due to their unique physical/chemical properties and biological compatibility and are among the most promising materials that have already changed and will keep changing human life. Recently, because of their functionalization and stability, carbon nanomaterials have been explored as a novel tool for the delivery of therapeutic cancer drugs. In this review, we present an overview of the development of carbon dot nanomaterials in the nanomedicine field by focusing on their synthesis, and structural and optical properties as well as their imaging, therapy and cargo delivery applications.
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