Journal
NANOSCALE HORIZONS
Volume 6, Issue 10, Pages 766-780Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nh00299f
Keywords
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Funding
- National Natural Science Foundation of China [51872183]
- Shuguang Scholar of Shanghai Municipal Education Commission [19SG38]
- State Key Laboratory of Rare Earth Resources Utilization [RERU2016013]
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This review focuses on recent advances in detecting biomolecule activities based on lanthanide luminescent systems, including upconversion luminescent nanoparticles, lanthanide-metal organic frameworks, and lanthanide organic complexes. It also discusses the design principles, sensing mechanisms, challenges, and perspectives for practical achievements of lanthanide probes.
Biomolecules play critical roles in biological activities and are closely related to various disease conditions. The reliable, selective and sensitive detection of biomolecules holds much promise for specific and rapid biosensing. In recent years, luminescent lanthanide probes have been widely used for monitoring the activity of biomolecules owing to their long luminescence lifetimes and line-like emission which allow time-resolved and ratiometric analyses. In this review article, we concentrate on recent advances in the detection of biomolecule activities based on lanthanide luminescent systems, including upconversion luminescent nanoparticles, lanthanide-metal organic frameworks, and lanthanide organic complexes. We also introduce the latest remarkable accomplishments of lanthanide probes in the design principles and sensing mechanisms, as well as the forthcoming challenges and perspectives for practical achievements.
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