A tumor-cell biomimetic nanoplatform embedding biological enzymes for enhanced metabolic therapy

A tumor cell membrane-camouflaged therapeutic system was fabricated to eliminate tumors by embedding apyrase and glucose oxidase (GOx) into zeolitic imidazolate framework-8 (ZIF-8) nanoparticles for tumor-targeted metabolic therapy. Experimental results demonstrated that these functional nanoparticles could disturb the energy supply of tumor cells by depleting ATP and glucose and efficiently induce tumor cell death.

Automated summary

The tumor cell membrane-camouflaged therapeutic system, embedding apyrase and glucose oxidase into nanoparticles, was shown to disrupt tumor cell energy supply by depleting ATP and glucose, leading to efficient tumor cell death.