Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 72, Pages 9010-9028Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc03439a
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Funding
- SERB-DST research grant, Govt. of India [CRG/2018/001111]
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The chemistry of cyclic N-sulfonyl ketimines and their derivatives has attracted attention due to their intriguing structures and properties. These compounds serve as reactive synthons in various reactions and can create a diverse set of synthetically and biologically attractive molecules. Chemists focus on manipulating the highly reactive C=N bond of N-sulfonyl ketimines in synthetic reactions to form a wide range of fascinating compounds.
The chemistry related to the exploration of cyclic N-sulfonyl ketimines and their derivatives has attracted significant attention in the East few decades because of their intriguing structures and properties. They serve broadly as reactive synthons in various reactions to create a diverse set of synthetically and biologically attractive molecules. Furthermore, these moieties, which possess multiple heteroatoms (N, O and S), display or can enhance many biological activities. In the case of synthetic reactions, chemists mainly focus on the chemical manipulation of the highly reactive prochiral C=N bond of N-sulfonyl ketimines. Besides their traditional role as electrophiles, N-sulfonyl ketimines possess alpha-Csp(3)-H protons, and thus behave as potential carbonucleophiles, where they can undergo several C-X (X = C, N and O) bond-forming reactions with different types of electrophiles under various conditions to form a wide range of fascinating asymmetric and non-asymmetric versions of fused heterocycles, carbocycles, spiro-fused skeletons, pyridines, pyrroles, etc. Herein, we highlight the recent examples from our research work and others covering the scope of cyclic N-sulfonyl ketimines as useful carbonucleophiles. In addition, the detailed mechanistic studies of the above-mentioned reactions are also presented.
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