Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 9, Issue 37, Pages 7633-7661Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb00850a
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Funding
- National Natural Science Foundation of China [21675091, 21874078, 22074072]
- Taishan Young Scholar Program of Shandong Province [tsqn20161027]
- Major Science and Technology Innovation Project of Shandong Province [2018CXGC1407]
- Key Research and Development Project of Shandong Province [2016GGX102028, 2016GGX102039, 2017GGX20111]
- First-Class Discipline Project of Shandong Province
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Ultrasound contrast agents have been extensively studied and applied at the molecular level, expanding their application range and increasing their value in the medical field.
With the rapid development of molecular imaging, ultrasound (US) medicine has evolved from traditional imaging diagnosis to integrated diagnosis and treatment at the molecular level. Ultrasound contrast agents (UCAs) play a crucial role in the integration of US diagnosis and treatment. As the micro-bubbles (MBs) in UCAs can enhance the cavitation effect and promote the biological effect of US, UCAs have also been studied in the fields of US thrombolysis, mediated gene transfer, drug delivery, and high intensity focused US. The application range of UCAs is expanding, and the value of their applications is improving. This paper reviews the development and application of UCAs in biomedicine in recent years, and the existing problems and prospects are pointed out.
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