Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 112, Issue -, Pages 143-147Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2016.11.024
Keywords
Pluronic (R) F127; Chitosan; Mucosal passage; Thermosensitive; Hydrogel; Trichomonas vaginalis
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Funding
- la Region Ile de France
- Institut Universitaire de France
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The objective of this work is to design topically-applied thermosensitive and mucoadhesive hydrogel containing metronidazole (MTZ) for the treatment of Trichomonas vaginalis infections. Hydrogel composed of pluronic (R) F127 (20 wt%), chitosan (1 wt%) and metronidazole MTZ (0.7 wt%) mixture showed its ability to decrease by a factor 4 MTZ flux and apparent permeability absorption through vaginal mucosa. The impact of hydrogel on transmucosal penetration of MTZ was evaluated ex vivo on excised porcine vaginal mucosa mounted on Franz diffusion cell. The anti-T. vaginalis activity of MTZ formulated into F127/chitosan hydrogel was preserved since the viability curve evaluated in vitro was similar to MTZ solution. (C) 2016 Elsevier B.V. All rights reserved.
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