Journal
JOURNAL OF TISSUE ENGINEERING
Volume 12, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/20417314211028574
Keywords
3D bioprinting; skin; skin appendages; tissue engineering; regenerative medicine
Categories
Funding
- National key research and development project [2016YFC1100800, 2016YFC1100803]
- National Natural Science Foundation of China [81772069, 81401591, 81801911]
- Zhejiang Provincial Basic Public Welfare Research Program [LGF19H150008]
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3D bioprinting is a rapidly reliable method for skin regeneration, with the ability to customize skin shape and high resolution, flexibility, and reproducibility. It shows great potential in the fabrication of tissue-engineered skin.
Skin and skin appendages are vulnerable to injury, requiring rapidly reliable regeneration methods. In recent years, 3D bioprinting has shown potential for wound repair and regeneration. 3D bioprinting can be customized for skin shape with cells and other materials distributed precisely, achieving rapid and reliable production of bionic skin substitutes, therefore, meeting clinical and industrial requirements. Additionally, it has excellent performance with high resolution, flexibility, reproducibility, and high throughput, showing great potential for the fabrication of tissue-engineered skin. This review introduces the common techniques of 3D bioprinting and their application in skin tissue engineering, focusing on the latest research progress in skin appendages (hair follicles and sweat glands) and vascularization, and summarizes current challenges and future development of 3D skin printing.
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