Journal
JOURNAL OF CANCER
Volume 12, Issue 19, Pages 5895-5902Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.60893
Keywords
tumor microenvironment; cancer stem cell; matrix stiffness; shear stress; compression and tension
Categories
Funding
- National Natural Science Foundation of China [31871413]
- Programs of Guangdong Science and Technology [2017B020230002, 2016B030231001]
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This paper discusses the impact of mechanical components on cancer stem cells and explores the intrinsic correlation between them, providing potential regulatory mechanisms for clinical applications and offering different perspectives for drug and treatment design.
Cancer stem cells (CSCs), dynamic subsets of cancer cells, are responsible for malignant progression. The unique properties of CSCs, including self-renewal, differentiation, and malignancy, closely depend on the tumor microenvironment. Mechanical components in the microenvironment, including matrix stiffness, fluid shear stress, compression and tension stress, affect the fate of CSCs and further influence the cancer process. This paper reviews recent studies of mechanical components and CSCs, and further discusses the intrinsic correlation among them. Regulatory mechanisms of mechanical microenvironment, which act on CSCs, have great potential for clinical application and provide different perspectives to drugs and treatment design.
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