3.8 Article

Ethical Challenges in Organoid Use

Journal

BIOTECH
Volume 10, Issue 3, Pages -

Publisher

MDPI
DOI: 10.3390/biotech10030012

Keywords

organoids; biobanking; ethics; bioethics; regulation

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Organoid technology holds great promise in biomedicine and biotechnology, but also raises complex ethical challenges. This study analyzes the multifaceted ethical issues and recommends measures to ensure ethical use and application of the technology. Despite the challenges, it is concluded that there is a moral obligation to support organoid research to maximize benefits and contribute to future governance models in the field.
Organoids hold great promises for numerous applications in biomedicine and biotechnology. Despite its potential in science, organoid technology poses complex ethical challenges that may hinder any future benefits for patients and society. This study aims to analyze the multifaceted ethical issues raised by organoids and recommend measures that must be taken at various levels to ensure the ethical use and application of this technology. Organoid technology raises several serious ethics issues related to the source of stem cells for organoid creation, informed consent and privacy of cell donors, the moral and legal status of organoids, the potential acquisition of human characteristics or qualities, use of gene editing, creation of chimeras, organoid transplantation, commercialization and patentability, issues of equity in the resulting treatments, potential misuse and dual use issues and long-term storage in biobanks. Existing guidelines and regulatory frameworks that are applicable to organoids are also discussed. It is concluded that despite the serious ethical challenges posed by organoid use and biobanking, we have a moral obligation to support organoid research and ensure that we do not lose any of the potential benefits that organoids offer. In this direction, a four-step approach is recommended, which includes existing regulations and guidelines, special regulatory provisions that may be needed, public engagement and continuous monitoring of the rapid advancements in the field. This approach may help maximize the biomedical and social benefits of organoid technology and contribute to future governance models in organoid technology.

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