4.5 Review

Type I Interferons in COVID-19 Pathogenesis

Related references

Note: Only part of the references are listed.
Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Cytokine profile and disease severity in patients with COVID-19

Ali Ghazavi et al.

Summary: Cytokine dysregulation is proposed as the mechanism for COVID-19. This study evaluated serum cytokines levels in COVID-19 patients, finding elevated levels of IFN-gamma, TGF-beta, IL-17, and IL-8 compared to the control group, with significant differences in TGF-beta levels between mild and severe groups, and no significant differences in IL-5 and IL-9 levels.

CYTOKINE (2021)

Article Infectious Diseases

An open-label randomized controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-β-1a and hydroxychloroquine in hospitalized patients with COVID-19

Florence Ader et al.

Summary: This study evaluated the clinical, virological, and safety outcomes of different treatment options in hospitalized COVID-19 patients, showing that lopinavir/ritonavir, lopinavir/ritonavir-IFN-beta-1a, and hydroxychloroquine did not improve the clinical status or SARS-CoV-2 clearance in respiratory tract specimens.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Article Multidisciplinary Sciences

Genetic mechanisms of critical illness in COVID-19

Erola Pairo-Castineira et al.

Summary: In critically ill patients with COVID-19, host genetic variants associated with antiviral defense mechanisms and inflammatory organ damage were identified through a genome-wide association study. These genetic signals provide potential targets for therapeutic development and repurposing of existing drugs. Large-scale randomized clinical trials will be essential to confirm the effectiveness of targeted treatment strategies.

NATURE (2021)

Article Biochemistry & Molecular Biology

Immune determinants of COVID-19 disease presentation and severity

Petter Brodin

Summary: The severity of COVID-19 varies by sex and age, and is linked to comorbidities. Differences in immune reactions may go some way to explain this.

NATURE MEDICINE (2021)

Article Virology

Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19)

Carolina Scagnolari et al.

Summary: The heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated with disease severity.

VIRUS RESEARCH (2021)

Article Virology

SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-beta Production

Keli Chen et al.

Summary: The nucleocapsid (N) protein of SARS-CoV-2 plays a crucial role in inhibiting interferon beta production by interacting with the key component RIG-I in the RNA recognition pathway, potentially affecting the host's immune response.

VIRUSES-BASEL (2021)

Review Cell Biology

COVID-19: Characteristics and Therapeutics

Rameswari Chilamakuri et al.

Summary: The novel coronavirus (COVID-19) has significantly impacted the world since its emergence at the end of 2019, but there have been major advancements in our understanding of the virus and development of treatment options and vaccines to control the pandemic.

CELLS (2021)

Article Microbiology

Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

Jing-wen Lin et al.

Summary: This study utilized an integrative approach to analyze mutations of the SARS-CoV-2 virus, identifying 35 recurrent variants of clinical importance, with one variant associated with severe clinical phenotypes. The findings suggest that mutations in Nsp1 may have implications for molecular diagnostics and drug design.

CELL HOST & MICROBE (2021)

Article Immunology

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation

Wenjing Wang et al.

Summary: The study found that SARS-CoV-2 nsp12 suppresses host antiviral responses by attenuating specific IFN promoter activation and impacting the function of IRF3. These findings provide new insights into the viral pathogenesis.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Type I and III IFN-mediated antiviral actions counteracted by SARS-CoV-2 proteins and host inherited factors

Jorge Quarleri et al.

Summary: Research has shown that SARS-CoV-2 infection can lead to different patterns of disease progression, with interferon playing a key role in the process. The effectiveness of IFN and its role in disease outcomes are influenced by both viral and host factors.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

Article Immunology

Plasma Exchange to Rescue Patients with Autoantibodies Against Type I Interferons and Life-Threatening COVID-19 Pneumonia

Nicolas de Prost et al.

Summary: This study reported four cases of life-threatening COVID-19 pneumonia in patients with high blood concentrations of neutralizing autoantibodies against type I interferons, who were treated with plasma exchange. The results showed that plasma exchange efficiently removes autoantibodies against type I interferons in these patients without affecting anti-SARS-CoV-2 antibody levels.

JOURNAL OF CLINICAL IMMUNOLOGY (2021)

Article Cell Biology

SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO

Jing Wu et al.

Summary: SARS-CoV-2 activates and represses the innate immune response, leading to dysregulation and delayed interferon expression, which contribute to the development of COVID-19. The study reveals that ORF9b inhibits the type I interferon response during SARS-CoV-2 infection.

CELL REPORTS (2021)

Article Biology

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

Chiara Fallerini et al.

Summary: Loss-of-function variants in TLR7 were found to be associated with severe COVID-19 in young males, representing a subset of male patients and contributing to disease susceptibility in approximately 2% of severe COVID-19 cases. This study provides insight into the genetic factors influencing COVID-19 severity in male patients.

ELIFE (2021)

Article Critical Care Medicine

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

Phillip D. Monk et al.

Summary: The study evaluated the efficacy and safety of using interferon beta-1a to treat COVID-19, with results showing that patients who received treatment had higher and faster recovery rates, providing potential evidence for further clinical trials.

LANCET RESPIRATORY MEDICINE (2021)

Article Chemistry, Medicinal

The Effect of Recombinant Human Interferon Alpha Nasal Drops to Pre-vent COVID-19 Pneumonia for Medical Staff in an Epidemic Area

Zhongji Meng et al.

Summary: This study investigated the effectiveness and safety of rhIFN-alpha nasal drops for the prevention of COVID-19 among medical staff. The results showed that both low-risk and high-risk groups did not develop COVID-19 pneumonia after thirty days, and no serious adverse events were observed during the intervention.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2021)

Article Virology

SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways

Lulu Han et al.

Summary: The SARS-CoV-2 ORF9b protein inhibits the production of type I and type III interferons by targeting multiple molecules of innate antiviral signaling pathways, thus facilitating viral replication.

JOURNAL OF MEDICAL VIROLOGY (2021)

Article Immunology

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

Min Zheng et al.

Summary: The study revealed that the envelope protein of SARS-CoV-2 is sensed by TLR2, leading to the production of inflammatory cytokines, and the severity of the disease is associated with the expression of TLR2 and MYD88. The findings demonstrate the critical role of TLR2 signaling in promoting proinflammatory cytokine production during coronavirus infection, providing new insights for therapeutic strategies against the ongoing COVID-19 pandemic.

NATURE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway

Andrea R. Daamen et al.

Summary: Analysis of gene expression data from COVID-19 patients revealed that the inflammatory response is mainly driven by populations of myeloid-lineage cells. Delayed virus clearance may lead to exaggerated activation of these cells, contributing to disease pathogenesis through the production of inflammatory mediators.

SCIENTIFIC REPORTS (2021)

Article Cell Biology

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

Manuel Hayn et al.

Summary: SARS-CoV-2 proteins synergize to counteract innate immune responses, but they are vulnerable to type II and III interferons. Experimental results show potent inhibition of SARS-CoV-2 infection by interferon-gamma and lambda 1, highlighting potential for effective antiviral approaches.

CELL REPORTS (2021)

Article Virology

SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist

Aixin Li et al.

Summary: Our study revealed that while NSP12 could suppress IFN-beta promoter luciferase activity, it did not inhibit IFN-beta production or downstream signaling. Additionally, caution is needed when interpreting SARS-CoV-2-related luciferase assays due to potential contradictory results from different experimental systems.

JOURNAL OF VIROLOGY (2021)

Article Multidisciplinary Sciences

Combination of (interferon beta-1b, lopinavir/ritonavir and ribavirin) versus favipiravir in hospitalized patients with non-critical COVID-19: A cohort study

Areej A. Malhani et al.

Summary: The study found that early IFN-based triple therapy in non-critical COVID-19 patients was associated with significantly lower 28-day mortality compared to FPV. The IFN-based therapy group required less use of systemic corticosteroids and experienced more nausea and diarrhea compared to the FPV group.

PLOS ONE (2021)

Article Biochemistry & Molecular Biology

SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block

James M. Burke et al.

Summary: The study found that during SARS-CoV-2 infection, the biogenesis of IFN mRNAs is inhibited at multiple steps, including limited translocation of transcription factor IRF3 to the nucleus, localization of IFN mRNAs primarily at the site of transcription in most infected cells, and inhibition of nuclear-cytoplasmic transport. These results suggest that SARS-CoV-2 weakens the transcriptional induction of IFN genes through multiple mechanisms, inhibiting the production of interferon proteins in host cells and affecting the antiviral immune response.
Article Medicine, Research & Experimental

Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19

Gundula Povysil et al.

Summary: The study found no evidence of association between rare pLOF variants in 13 candidate genes and severe COVID-19 outcomes. Only one rare pLOF mutation was identified across these genes among cases with severe COVID-19, and there was no enrichment of pLOFs in severe cases compared to controls or mild COVID-19 cases.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Immunology

SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response

Yu-Zhi Fu et al.

Summary: A novel SARS-related coronavirus (SARS-CoV-2) has emerged as a serious pathogen causing high morbidity and mortality. The membrane glycoprotein M of SARS-CoV-2 was identified as a negative regulator of the innate immune response by impairing MAVS aggregation and downstream signaling, thus evading the innate antiviral response.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Physiology

SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection

Theodore G. Liou et al.

Summary: The study found that in early COVID-19 infection, N1 protein transcript load increased as well as ACE-2 transcripts. Transcripts for two interferons, IFN-lambda 1 and IFN-lambda 2, were elevated and closely associated with viral N1 transcripts. Older age was associated with substantial modifications of some effects. The findings suggest a disrupted immune landscape in patients with early disease, characterized by an innate immune response with elevated interferon, proinflammatory cytokine, and interferon-stimulated gene transcripts, but also evidence of a viral-induced shut-off of host antiviral responses.

PHYSIOLOGICAL REPORTS (2021)

Review Immunology

Innate Immune Evasion by Human Respiratory RNA Viruses

Marjolein Kikkert

JOURNAL OF INNATE IMMUNITY (2020)

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

Article Medicine, General & Internal

Clinical Characteristics of Coronavirus Disease 2019 in China

W. Guan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Biochemistry & Molecular Biology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo et al.

Editorial Material Biochemistry & Molecular Biology

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Jean-Laurent Casanova et al.

Article Microbiology

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

Zhuo Zhou et al.

CELL HOST & MICROBE (2020)

Article Microbiology

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Evangelos J. Giamarellos-Bourboulis et al.

CELL HOST & MICROBE (2020)

Review Biochemistry & Molecular Biology

The global impact of the coronavirus pandemic

John Hiscott et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

Article Allergy

Type I IFN immunoprofiling in COVID-19 patients

Sophie Trouillet-Assant et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Medicine, Research & Experimental

Clinical and immunological features of severe and moderate coronavirus disease 2019

Guang Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Virology

Virology, Epidemiology, Pathogenesis, and Control of COVID-19

Yuefei Jin et al.

VIRUSES-BASEL (2020)

Review Endocrinology & Metabolism

Impact of sex and gender on COVID-19 outcomes in Europe

Catherine Gebhard et al.

BIOLOGY OF SEX DIFFERENCES (2020)

Article Immunology

Interferon-α2b Treatment for COVID-19

Qiong Zhou et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Viral and host factors related to the clinical outcome of COVID-19

Xiaonan Zhang et al.

NATURE (2020)

Letter Biochemistry & Molecular Biology

The proximal origin of SARS-CoV-2

Kristian G. Andersen et al.

NATURE MEDICINE (2020)

Article Public, Environmental & Occupational Health

Gender Differences in Patients With COVID-19: Focus on Severity and Mortality

Jian-Min Jin et al.

FRONTIERS IN PUBLIC HEALTH (2020)

Article Microbiology

A Randomized Clinical Trial of the Efficacy and Safety of Interferon β-1a in Treatment of Severe COVID-19

Effat Davoudi-Monfared et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

Article Immunology

Subcutaneous administration of interferon beta-1a for COVID-19: A non-controlled prospective trial

Farzaneh Dastan et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Article Medicine, General & Internal

Presence of Genetic Variants Among Young Men With Severe COVID-19

Caspar I. van der Made et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Letter Virology

Type I interferons can be detected in respiratory swabs from SARS-Cov-2 infected patients

Guido Antonelli et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

Review Medicine, General & Internal

COVID-19 and Sex Differences: Mechanisms and Biomarkers

Tu Haitao et al.

MAYO CLINIC PROCEEDINGS (2020)

Article Multidisciplinary Sciences

Factors associated with COVID-19-related death using OpenSAFELY

Elizabeth J. Williamson et al.

NATURE (2020)

Article Multidisciplinary Sciences

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Carolina Lucas et al.

NATURE (2020)

Article Multidisciplinary Sciences

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Jerome Hadjadj et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Activation and evasion of type I interferon responses by SARS-CoV-2

Xiaobo Lei et al.

NATURE COMMUNICATIONS (2020)

Article Medicine, Research & Experimental

Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population

Sabra Klein et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Virology

Type I Interferon Susceptibility Distinguishes SARS-CoV-2 from SARS-CoV

Kumari G. Lokugamage et al.

JOURNAL OF VIROLOGY (2020)

Article Multidisciplinary Sciences

Sex differences in immune responses that underlie COVID-19 disease outcomes

Takehiro Takahashi et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

Katharina Schubert et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

Lisa Miorin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian Zhang et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard et al.

SCIENCE (2020)

Editorial Material Medicine, General & Internal

Virology, transmission, and pathogenesis of SARS-CoV-2

Muge Cevik et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Article Cell Biology

Evasion of Type I Interferon by SARS-CoV-2

Hongjie Xia et al.

CELL REPORTS (2020)

Article Biochemistry & Molecular Biology

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

Nicole A. P. Lieberman et al.

PLOS BIOLOGY (2020)

Article Multidisciplinary Sciences

Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission

Hannah Peckham et al.

NATURE COMMUNICATIONS (2020)

Article Immunology

Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients

Maria Caridad Montalvo Villalba et al.

CLINICAL IMMUNOLOGY (2020)

Article Immunology

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

Chun-Kit Yuen et al.

EMERGING MICROBES & INFECTIONS (2020)

Article Medicine, Research & Experimental

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

Rudragouda Channappanavar et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Virology

Bats and Coronaviruses

Arinjay Banerjee et al.

VIRUSES-BASEL (2019)

Review Immunology

The Dual Nature of Type I and Type II Interferons

Amanda J. Lee et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Microbiology

Ten Strategies of Interferon Evasion by Viruses

Adolfo Garcia-Sastre

CELL HOST & MICROBE (2017)

Review Immunology

Sex differences in immune responses

Sabra L. Klein et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Review Biochemistry & Molecular Biology

Twenty-five years of type I interferon-based treatment: A critical analysis of its therapeutic use

Guido Antonelli et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2015)

Review Infectious Diseases

Sex differences in immune responses to infectious diseases

Julia Fischer et al.

INFECTION (2015)

Review Immunology

Type I interferons in infectious disease

Finlay McNab et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Physiology

Animal models of acute lung injury

Gustavo Matute-Bello et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

Review Biochemistry & Molecular Biology

Triggering the innate antiviral response through IRF-3 activation

John Hiscott

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Immunology

Interferon-β 1a and SARS coronavirus replication

LE Hensley et al.

EMERGING INFECTIOUS DISEASES (2004)