PRESERVATION OF VITAMIN-E AGAINST NEPHROTOXIC EFFECT INDUCED BY SUBACUTE DICHLORVOS APPLICATION

In this study, it was aimed to determine the potential toxic effect of organophosphate dichlorvos applications, which is used as a broad spectrum insecticide in agricultural activities through food chain and the protection of vitamin E against it. In this study, 40 Sprague Dawley male rats were used. The corn oil was given intragastrically as 5 ml kg(-1). In the second group, 5 mg kg(-1) dose of dichlorvos was applied intragastrically after dissolving in corn oil. The third group, 120 mg kg(-1) vitamin E application was started intragastrically by starting three days before the application of dichlorvos, and the following days were applied in the same way at 5 mg kg(-1) doses after 1 hour vit-E application. In the last group, vit-E was given intragastrically at a dose of only 120 mg kg(-1). Histological examination of renal tissue revealed normal structures in control and Vitamin-E groups, whereas glomerular atrophy, inflammatory cell infiltrations and tubular degeneration areas were observed in the dichlorvos group. Vit-E in combination with dichlorvos decreased the severity of the lesions. PON and HDL levels were decreased compared to the control group and increased in MDA and NO levels due to toxicity caused by inflammation in the dichlorvos group. When Dichlorvos and vit-E were applied together, PON and HDL levels were increased and MDA and NO levels were decreased when compared to only dichlorvos group. It has been concluded that vit-E supplementation would be beneficial in addition to routine medical treatment in living beings exposed to dichlorvos poisoning.

Automated summary

The study confirmed the protective effect of vitamin E against dichlorvos toxicity, which can help reduce renal tissue damage in rats. Additionally, the toxic inflammation caused by dichlorvos can be alleviated through vitamin E supplementation.