Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 75, Pages 9554-9557Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc03738b
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Funding
- National Natural Science Foundation of China [21874085]
- National Key R&D Program of China [2019YFA0210100]
- Key Research and Development Program of Shandong Province [2018YFJH0502]
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Seven viscosity-sensitive probes were developed through simple structural modification of dicyanoisophorone (DCO)-derived dyes. Among them, DCO-5 showed a significant enhancement (180-fold) of response signal in highly viscous aqueous media, while remaining insensitive to changes in polarity or pH. It successfully detected viscosity changes in nystatin-treated HepG2 cells, PC 12 cells and zebrafish.
Herein, seven viscosity-sensitive probes were developed via simple structural modification of dicyanoisophorone (DCO)-derived dyes. Among them, DCO-5 significantly enhances (180-fold) the response signal in highly viscous aqueous media while showing insensitivity to polarity changes or pH variations, and enables the successful detection of viscosity changes in nystatin-treated HepG2 cells, PC 12 cells and zebrafish.
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