Journal
GENES & DISEASES
Volume 8, Issue 6, Pages 781-797Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.gendis.2020.10.002
Keywords
Bladder cancer; Carcinogenesis; Inflammatory microenvironment; Pathogenesis; Progression; Urinary microbiome
Funding
- National Nat-ural Science Foundation of China [81630080, 91129714, 81874380, 81730108, 81973635, 82022075]
- Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars [LR18H160001]
- National Key R&D Program of China [2018YFC1704100, 2018YFC1704106]
- Zhejiang prov-ince science and technology project of TCM [2019ZZ016]
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Chronic inflammation is closely linked to the development and progression of bladder cancer, with the microbiome playing an important role. The urinary microbiome may promote the initiation and progression of bladder cancer.
Accumulating evidence suggests that chronic inflammation may play a critical role in various malignancies, including bladder cancer. This hypothesis stems in part from inflammatory cells observed in the urethral microenvironment. Chronic inflammation may drive neoplastic transformation and the progression of bladder cancer by activating a series of inflammatory molecules and signals. Recently, it has been shown that the microbiome also plays an important role in the development and progression of bladder cancer, which can be mediated through the stimulation of chronic inflammation. In effect, the urinary microbiome can play a role in establishing the inflammatory urethral microenvironment that may facilitate the development and progression of bladder cancer. In other words, chronic inflammation caused by the urinary microbiome may promote the initiation and progression of bladder cancer. Here, we provide a detailed and comprehensive account of the link between chronic inflammation, the microbiome and bladder cancer. Finally, we highlight that targeting the urinary microbiome might enable the development of strategies for bladder cancer prevention and personalized treatment. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.
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