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SCIENTIFIC REPORTS (2016)
Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer
Randall F Holcombe et al.
Cancer Management and Research (2016)
TNIK inhibition abrogates colorectal cancer stemness
Mari Masuda et al.
NATURE COMMUNICATIONS (2016)
Expression and Mutation Pattern of β-Catenin and Adenomatous Polyposis Coli in Colorectal Cancer Patients
Rania Abdelmaksoud-Damak et al.
ARCHIVES OF MEDICAL RESEARCH (2015)
AXIN2 Polymorphisms, the β-Catenin Destruction Complex Expression Profile and Breast Cancer Susceptibility
Andres Felipe Aristizabal-Pachon et al.
Asian Pacific Journal of Cancer Prevention (2015)
The use of porcupine inhibitors to target Wnt-driven cancers
Soo Yei Ho et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Prognostic significance of Traf2-and Nck- interacting kinase (TNIK) in colorectal cancer
Hidenori Takahashi et al.
BMC CANCER (2015)
Wnt/ -Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells
G.-B. Jang et al.
CANCER RESEARCH (2015)
Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1
Michael Y. Choi et al.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2015)
Insights into Frizzled evolution and new perspectives
Quentin Schenkelaars et al.
EVOLUTION & DEVELOPMENT (2015)
Wnts grasp the WIF domain of Wnt Inhibitory Factor 1 at two distinct binding sites
Krisztina Kerekes et al.
FEBS LETTERS (2015)
TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer
Jin Boo Jeong et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)
A first-in-human phase I dose-escalation, pharmacokinetic, and pharmacodynamic evaluation of intravenous LY2090314, a glycogen synthase kinase 3 inhibitor, administered in combination with pemetrexed and carboplatin
Jhanelle E. Gray et al.
INVESTIGATIONAL NEW DRUGS (2015)
Wnt2 protein plays a role in the progression of pancreatic cancer promoted by pancreatic stellate cells
Yong Xu et al.
MEDICAL ONCOLOGY (2015)
HSP105 Recruits Protein Phosphatase 2A To Dephosphorylate β-Catenin
Nancy Yu et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells
Ozlem Kulak et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
Notum deacylates Wnt proteins to suppress signalling activity
Satoshi Kakugawa et al.
NATURE (2015)
Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer
Mari Masuda et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28
Phuong N. Le et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia
Bon-Kyoung Koo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment
Yue Cheng et al.
ONCOTARGET (2015)
Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells
Li Ma et al.
ONCOTARGET (2015)
IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression
Sang Chul Lee et al.
ONCOTARGET (2015)
WNT-1 inducible signaling pathway protein-1 enhances growth and tumorigenesis in human breast cancer
Kun-Chun Chiang et al.
SCIENTIFIC REPORTS (2015)
A novel GSK3-regulated APC: Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction
Mira I. Pronobis et al.
ELIFE (2015)
The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells
David Qualtrough et al.
CANCERS (2015)
Mutation of β-catenin in a radiation and estrogen breast cancer model
Debasish Roy et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2015)
Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells
W. Fiskus et al.
LEUKEMIA (2015)
Targeting WNT1-inducible signaling pathway protein 2 alters human breast cancer cell susceptibility to specific lysis through regulation of KLF-4 and miR-7 expression
I. Akalay et al.
ONCOGENE (2015)
Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma - Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3
Jennifer M. Atkinson et al.
PLOS ONE (2015)
Salinomycin inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cell in vitro and suppresses tumor growth in vivo
Danxin Wu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
Wnt3a expression is associated with MMP-9 expression in primary tumor and metastatic site in recurrent or stage IV colorectal cancer
Myung Ah Lee et al.
BMC CANCER (2014)
Wnt-Notch signalling crosstalk in development and disease
Giovanna M. Collu et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2014)
Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer Cells
Wenyan Lu et al.
CELLULAR SIGNALLING (2014)
Casein kinase 1 and Wnt/β-catenin signaling
Cristina-Maria Cruciat
CURRENT OPINION IN CELL BIOLOGY (2014)
Tankyrases: Structure, Function and Therapeutic Implications in Cancer
Teemu Haikarainen et al.
CURRENT PHARMACEUTICAL DESIGN (2014)
Tankyrase Inhibitors as Therapeutic Targets for Cancer
Ahmed Kamal et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2014)
Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice
Junyan Tao et al.
GASTROENTEROLOGY (2014)
Inhibition of Wnt/β-catenin pathway by niclosamide: A therapeutic target for ovarian cancer
Rebecca C. Arend et al.
GYNECOLOGIC ONCOLOGY (2014)
XAV939 inhibits the stemness and migration of neuroblastoma cancer stem cells via repression of tankyrase 1
Xiaohong Tian et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2014)
Isoquercitrin Suppresses Colon Cancer Cell Growth in Vitro by Targeting the Wnt/β-Catenin Signaling Pathway
Nathalia G. Amado et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Salinomycin Suppresses LRP6 Expression and Inhibits Both Wnt/β-catenin and mTORC1 Signaling in Breast and Prostate Cancer Cells
Wenyan Lu et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2014)
Wnt Signaling Pathway in Non-Small Cell Lung Cancer
David J. Stewart
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)
MicroRNA-195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells
Yang Yang et al.
MOLECULAR MEDICINE REPORTS (2014)
Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine
Xinxin Gao et al.
NATURE CHEMICAL BIOLOGY (2014)
TCTP promotes glioma cell proliferation in vitro and in vivo via enhanced β-catenin/TCF-4 transcription
Xuefeng Gu et al.
NEURO-ONCOLOGY (2014)
Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells
Benquan Wang et al.
ONCOLOGY REPORTS (2014)
Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway
Reinoud E. A. de Groot et al.
SCIENCE SIGNALING (2014)
Targeting the β-catenin nuclear transport pathway in cancer
Cara Jamieson et al.
SEMINARS IN CANCER BIOLOGY (2014)
SOX10 is a novel oncogene in hepatocellular carcinoma through Wnt/β-catenin/TCF4 cascade
Dangjun Zhou et al.
TUMOR BIOLOGY (2014)
Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP
Yingying Jia et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2014)
Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/β-catenin signaling
Marija Mojsin et al.
FOOD & FUNCTION (2014)
Quantitative assessment of the diagnostic role of APC promoter methylation in non-small cell lung cancer
Shicheng Guo et al.
CLINICAL EPIGENETICS (2014)
Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation
Andrea Venerando et al.
BIOCHEMICAL JOURNAL (2013)
Activator or inhibitor? GSK-3 as a new drug target
Fumi Takahashi-Yanaga
BIOCHEMICAL PHARMACOLOGY (2013)
Evidence for tankyrases as antineoplastic targets in lung cancer
Alexander M. Busch et al.
BMC CANCER (2013)
Celecoxib Downregulates CD133 Expression Through Inhibition of the Wnt Signaling Pathway in Colon Cancer Cells
Yanhong Deng et al.
CANCER INVESTIGATION (2013)
Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer
Kyle David Proffitt et al.
CANCER RESEARCH (2013)
A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth
Ted Lau et al.
CANCER RESEARCH (2013)
Caveolin-1-LRP6 Signaling Module Stimulates Aerobic Glycolysis in Prostate Cancer
Salahaldin A. Tahir et al.
CANCER RESEARCH (2013)
Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling
Youngwook Ahn et al.
DEVELOPMENT (2013)
APC gene hypermethylation and prostate cancer: a systematic review and meta-analysis
Yang Chen et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2013)
Wnt3a regulates proliferation, apoptosis and function of pancreatic NIT-1 beta cells via activation of IRS2/PI3K signaling
Shuyan Gui et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2013)
XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway
Xiao-Hong Tian et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2013)
The Development of Highly Potent Inhibitors for Porcupine
Xiaolei Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary
Georgina L. Ryland et al.
JOURNAL OF PATHOLOGY (2013)
Curcumin suppresses migration and proliferation of Hep3B hepatocarcinoma cells through inhibition of the Wnt signaling pathway
Hyun Jung Kim et al.
MOLECULAR MEDICINE REPORTS (2013)
Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction
Sheng Wang et al.
NATURE CHEMICAL BIOLOGY (2013)
Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with β-Catenin/TCF4 Interaction in Colorectal Cancer Cells
Xingyao Li et al.
PLOS ONE (2013)
The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer
Wei Xu et al.
PLOS ONE (2013)
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma
Xiaomo Jiang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Jun Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer
Min-Li Mo et al.
ONCOLOGY LETTERS (2013)
Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin
Matthias Zebisch et al.
NATURE COMMUNICATIONS (2013)
Inhibition of Wnt1 expression reduces the enrichment of cancer stem cells in a mouse model of breast cancer
A-Ram Choi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway
Hui Zhang et al.
CANCER LETTERS (2012)
A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice
Jo Waaler et al.
CANCER RESEARCH (2012)
FoxM1 and Wnt/β-Catenin Signaling in Glioma Stem Cells
Aihua Gong et al.
CANCER RESEARCH (2012)
Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation
Xinjun Zhang et al.
CELL (2012)
Wnt/β-Catenin Signaling and Disease
Hans Clevers et al.
CELL (2012)
Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells
Wenyan Lu et al.
CELLULAR SIGNALLING (2012)
Frizzled7 as an emerging target for cancer therapy
Taj D. King et al.
CELLULAR SIGNALLING (2012)
The many faces and functions of β-catenin
Tomas Valenta et al.
EMBO JOURNAL (2012)
Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice
Gui Jie Feng et al.
GASTROENTEROLOGY (2012)
Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells
Seong-Ho Lee et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2012)
Sox4 functions as a positive regulator of β-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial carcinomas
Makoto Saegusa et al.
LABORATORY INVESTIGATION (2012)
Expression of Wnt3 Activates Wnt/β-Catenin Pathway and Promotes EMT-like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells
Yanyuan Wu et al.
MOLECULAR CANCER RESEARCH (2012)
Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4
Koji Ueno et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Abstract C144: Treatment with -catenin antagonist BC2059 exhibits single agent efficacy and exerts superior activity with tyrosine kinase inhibitor (TKI) or histone deacetylase (HDAC) inhibitor against human AML, CML, and myeloproliferative neoplasm (MPN) progenitor cells.
W. Fiskus et al.
MOLECULAR CANCER THERAPEUTICS (2012)
XIAP Monoubiquitylates Groucho/TLE to Promote Canonical Wnt Signaling
Alison J. Hanson et al.
MOLECULAR CELL (2012)
Wnt3 gene expression promotes tumor progression in non-small cell lung cancer
Nariyasu Nakashima et al.
LUNG CANCER (2012)
Recurrent R-spondin fusions in colon cancer
Somasekar Seshagiri et al.
NATURE (2012)
Comprehensive molecular characterization of human colon and rectal cancer
Donna M. Muzny et al.
NATURE (2012)
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
Huai-Xiang Hao et al.
NATURE (2012)
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
Bon-Kyoung Koo et al.
NATURE (2012)
Tankyrase-targeted therapeutics: expanding opportunities in the PARP family
Jenna L. Riffell et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
Bryan A. Gibson et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor
Hakan Gunaydin et al.
PLOS ONE (2012)
R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5
Heinz Ruffner et al.
PLOS ONE (2012)
Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells
Renyue Bao et al.
PLOS ONE (2012)
Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo
Fan Wang et al.
PLOS ONE (2012)
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled
Daniele V. F. Tauriello et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
Austin Gurney et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Structural Basis of Wnt Recognition by Frizzled
Claudia Y. Janda et al.
SCIENCE (2012)
Targeted Disruption of the BCL9/β-Catenin Complex Inhibits Oncogenic Wnt Signaling
Kohichi Takada et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Frizzled and LRP5/6 Receptors for Wnt/β-Catenin Signaling
Bryan T. MacDonald et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)
An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid
Marc de la Roche et al.
NATURE COMMUNICATIONS (2012)
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance
James A. McCubrey et al.
ONCOTARGET (2012)
The R-spondin protein family
Wim B. M. de lau et al.
GENOME BIOLOGY (2012)
Wnt3a stimulation elicits G-protein-coupled receptor properties of mammalian Frizzled proteins
Alexey Koval et al.
BIOCHEMICAL JOURNAL (2011)
Streptonigrin inhibits β-Catenin/Tcf signaling and shows cytotoxicity in β-catenin-activated cells
Seyeon Park et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2011)
The anti-progestin RU-486 inhibits viability of MCF-7 breast cancer cells by suppressing WNT1
Peggy Benad et al.
CANCER LETTERS (2011)
Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth
Jo Waaler et al.
CANCER RESEARCH (2011)
Indirubins Decrease Glioma Invasion by Blocking Migratory Phenotypes in Both the Tumor and Stromal Endothelial Cell Compartments
Shante P. Williams et al.
CANCER RESEARCH (2011)
Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations
Takuya Osada et al.
CANCER RESEARCH (2011)
Inhibition of Wnt/β-Catenin Signaling by p38 MAP Kinase Inhibitors Is Explained by Cross-Reactivity with Casein Kinase Iδ/ε
Folkert Verkaar et al.
CHEMISTRY & BIOLOGY (2011)
Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6
Victoria E. Ahn et al.
DEVELOPMENTAL CELL (2011)
LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling
Andrei Glinka et al.
EMBO REPORTS (2011)
Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis
Gregory Peignon et al.
GUT (2011)
3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions
Noam Levaot et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Critical Scaffolding Regions of the Tumor Suppressor Axin1 Are Natively Unfolded
Maria Noutsou et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon carcinogenesis
Ching-Shu Lai et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2011)
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
Wim de Lau et al.
NATURE (2011)
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
Kunyoo Shin et al.
NATURE (2011)
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
Yue Zhang et al.
NATURE CELL BIOLOGY (2011)
IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ε and Wnt/β-catenin independent inhibition of mitotic spindle formation
J. K. Cheong et al.
ONCOGENE (2011)
Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway
Wenyan Lu et al.
PLOS ONE (2011)
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling
Kendra S. Carmon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Identification of 2,3,6-trisubstituted quinoxaline derivatives as a Wnt2/β-catenin pathway inhibitor in non-small-cell lung cancer cell lines
Sang-Bum Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Pathomechanisms Underlying X-Adrenoleukodystrophy: A Three-Hit Hypothesis
Inderjit Singh et al.
BRAIN PATHOLOGY (2010)
β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells
Jenny Yeung et al.
CANCER CELL (2010)
HIF-2α Enhances β-Catenin/TCF-Driven Transcription by Interacting with β-Catenin
Hyunsung Choi et al.
CANCER RESEARCH (2010)
Traf2-and Nck-Interacting Kinase Is Essential for Wnt Signaling and Colorectal Cancer Growth
Miki Shitashige et al.
CANCER RESEARCH (2010)
FZD4 as a Mediator of ERG Oncogene-Induced WNT Signaling and Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells
Santosh Gupta et al.
CANCER RESEARCH (2010)
Dishevelled: The hub of Wnt signaling
Chan Gao et al.
CELLULAR SIGNALLING (2010)
Oral supplementation of silibinin prevents colon carcinogenesis in a long term preclinical model
Nagarajan Sangeetha et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells
Pay-Chin Leow et al.
INVESTIGATIONAL NEW DRUGS (2010)
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
Curtis A. Thorne et al.
NATURE CHEMICAL BIOLOGY (2010)
Positive Feedback Regulation between Phospholipase D and Wnt Signaling Promotes Wnt-Driven Anchorage-Independent Growth of Colorectal Cancer Cells
Dong Woo Kang et al.
PLOS ONE (2010)
Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
Seth A. Ettenberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy
Chia-Chen Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The Leukemia-Associated Mllt10/Af10-Dot1lAreTcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis
Tokameh Mahmoudi et al.
PLOS BIOLOGY (2010)
Silibinin Suppresses Growth of Human Colorectal Carcinoma SW480 Cells in Culture and Xenograft through Down-regulation of β-Catenin-Dependent Signaling
Manjinder Kaur et al.
NEOPLASIA (2010)
Small Molecule Inhibitors of Wnt/β-Catenin/Lef-1 Signaling Induces Apoptosis in Chronic Lymphocytic Leukemia Cells In Vitro and In Vivo
Rajesh Kumar Gandhirajan et al.
NEOPLASIA (2010)
The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling
Minyong Chen et al.
BIOCHEMISTRY (2009)
Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1 and Survivin Expression through Wnt/-Catenin Signaling Pathway
Bao-En Shan et al.
CANCER INVESTIGATION (2009)
BCL9 Promotes Tumor Progression by Conferring Enhanced Proliferative, Metastatic, and Angiogenic Properties to Cancer Cells
Mala Mani et al.
CANCER RESEARCH (2009)
Potent growth suppressive activity of curcumin in human breast cancer cells: Modulation of Wnt/β-catenin signaling
Chandra P. Prasad et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2009)
The kinase TNIK is an essential activator of Wnt target genes
Tokameh Mahmoudi et al.
EMBO JOURNAL (2009)
Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells
Katharina Salome Minke et al.
EUROPEAN JOURNAL OF HAEMATOLOGY (2009)
Wnt-5a-induced Phosphorylation of DARPP-32 Inhibits Breast Cancer Cell Migration in a CREB-dependent Manner
Christian Hansen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled
David Grandy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
PR55α, a Regulatory Subunit of PP2A, Specifically Regulates PP2A-mediated β-Catenin Dephosphorylation
Wen Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The F-box Protein β-TrCp1/Fbw1a Interacts with p300 to Enhance β-Catenin Transcriptional Activity
Erin A. Kimbrel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
Shih-Min A. Huang et al.
NATURE (2009)
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
Baozhi Chen et al.
NATURE CHEMICAL BIOLOGY (2009)
Ethacrynic Acid Exhibits Selective Toxicity to Chronic Lymphocytic Leukemia Cells by Inhibition of the Wnt/β-Catenin Pathway
Desheng Lu et al.
PLOS ONE (2009)
Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
Rajat Rohatgi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Wnt-expressing rat embryonic fibroblasts suppress Apo2L/TRAIL-induced apoptosis of human leukemia cells
Lenka Doubravska et al.
APOPTOSIS (2008)
RUNX3 attenuates β-catenin/T cell factors in intestinal tumorigenesis
Kosei Ito et al.
CANCER CELL (2008)
Inhibition of cyclin D1 gene transcription by Brg-1
Mahadev Rao et al.
CELL CYCLE (2008)
Sulindac suppresses β-catenin expression in human cancer cells
Anjia Han et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19(Arf)/p53 pathway lesions but not p16(Ink4a) loss
Michael T. Debies et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/β-catenin signaling pathway in hepatocellular carcinoma cells
Miran Kim et al.
JOURNAL OF HEPATOLOGY (2008)
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3-and c-Jun n-terminal kinase-dependent mechanism
Yoshimi Endo et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
APC Is Essential for Targeting Phosphorylated β-Catenin to the SCFβ-TrCP Ubiquitin Ligase
YunYun Su et al.
MOLECULAR CELL (2008)
Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression
Qiang Wei et al.
LUNG CANCER (2008)
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
Ron Firestein et al.
NATURE (2008)
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis
Weidong Zhu et al.
NATURE (2008)
PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)
Veerle Janssens et al.
TRENDS IN BIOCHEMICAL SCIENCES (2008)
Lithium inhibits proliferation of human esophageal cancer cell line Eca-109 by inducing a G2/M cell cycle arrest
Jin-Sheng Wang et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2008)
Frizzled-7 as a potential therapeutic target in colorectal cancer
Koji Ueno et al.
NEOPLASIA (2008)
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions
Xin Zeng et al.
DEVELOPMENT (2008)
Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function
Ramesh A. Bhat et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
An LRP5-receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/β-catenin signaling
Peyman Bjorklund et al.
PLOS MEDICINE (2007)
Sox17 and Sox4 Differentially Regulate β-catenin/T-cell factor activity and proliferation of colon carcinoma cells
Debora Sinner et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Involvement of RNA helicases p68 and p72 in colon cancer
Sook Shin et al.
CANCER RESEARCH (2007)
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
Josipa Bilic et al.
SCIENCE (2007)
The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization
Thomas Schwarz-Romond et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a
Hideyuki Komekado et al.
GENES TO CELLS (2007)
Protein phosphatase 1 regulates assembly and function of the β-catenin degradation complex
Wen Luo et al.
EMBO JOURNAL (2007)
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling
Manabu Kurayoshi et al.
BIOCHEMICAL JOURNAL (2007)
Wnt3A activates canonical Wnt signalling in acute lymphoblastic leukaemia (ALL) cells and inhibits the proliferation of B-ALL cell lines
Marit Kveine Nygren et al.
BRITISH JOURNAL OF HAEMATOLOGY (2007)
Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia
Abderrahmane Kaidi et al.
NATURE CELL BIOLOGY (2007)
An antagonist of dishevelled protein-protein interaction suppresses β-catenin-dependent tumor cell growth
Naoaki Fujii et al.
CANCER RESEARCH (2007)
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme
Uhn Soo Cho et al.
NATURE (2007)
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
Sandrine Boyault et al.
HEPATOLOGY (2007)
A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients
Thomas W. Flaig et al.
INVESTIGATIONAL NEW DRUGS (2007)
Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion
Ritsuko Takada et al.
DEVELOPMENTAL CELL (2006)
Mutations and nuclear accumulation of β-catenin correlate with intestinal phenotypic expression in human gastric cancer
N. Ogasawara et al.
HISTOPATHOLOGY (2006)
Singapore familial adenomatous polyposis (FAP) patients with classical adenomatous polyposis but undetectable APC mutations have accelerated cancer progression
Xia Cao et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2006)
Wnt/β-catenin signaling in development and disease
Hans Clevers
CELL (2006)
Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer
TA Hughes et al.
CANCER LETTERS (2006)
Evidence for the direct involvement of βTrCP in Gli3 protein processing
BW Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Peptides and peptidomimetics in medicine, surgery and biotechnology
Luca Gentilucci et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Comparing antibody and small-molecule therapies for cancer
Kohzoh Imai et al.
NATURE REVIEWS CANCER (2006)
Casein kinase 1γ couples Wnt receptor activation to cytoplasmic signal transduction
G Davidson et al.
NATURE (2005)
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
X Zeng et al.
NATURE (2005)
Role of antibody-dependent cell-mediated cytotoxicity in the efficacy of therapeutic anti-cancer monoclonal antibodies
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CANCER AND METASTASIS REVIEWS (2005)
Therapeutic potential of antibodies against FZD10, a cell-surface protein, for synovial sarcomas
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ONCOGENE (2005)
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
M Semënov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation
C Jung et al.
BRITISH JOURNAL OF CANCER (2005)
Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5
ZS Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Targeting the beta-catenin/APC pathway:: a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells
TJ Maier et al.
FASEB JOURNAL (2005)
The casein kinase I family:: participation in multiple cellular processes in eukaryotes
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CELLULAR SIGNALLING (2005)
Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
BA He et al.
ONCOGENE (2005)
β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
DL Daniels et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Exon 3 β-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome
V Johnson et al.
GUT (2005)
Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer
L Lammi et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4
CY Jung et al.
CANCER RESEARCH (2004)
APC mutations are infrequent but present in human lung cancer
H Ohgaki et al.
CANCER LETTERS (2004)
Wnt proteins in mammary development and cancer
KR Brennan et al.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2004)
Acetylation of β-catenin by p300 regulates β-catenin-Tcf4 interaction
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MOLECULAR AND CELLULAR BIOLOGY (2004)
Mechanism of phosphorylation-dependent binding of APC to β-catenin and its role in β-catenin degradation
NC Ha et al.
MOLECULAR CELL (2004)
Crystal structure of a β-Catenin/APC complex reveals a critical role for APC phosphorylation in APC function
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MOLECULAR CELL (2004)
Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): Combining anti-EGFR antibody with tyrosine kinase inhibitor
SM Huang et al.
CANCER RESEARCH (2004)
LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering β-catenin subcellular distribution
YH Li et al.
ONCOGENE (2004)
The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton
K Taira et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize β-catenin independently of Frizzled proteins
K Brennan et al.
ONCOGENE (2004)
Crystal structure of a β-catenin/axin complex suggests a mechanism for the β-catenin destruction complex
Y Xing et al.
GENES & DEVELOPMENT (2003)
Gli proteins and the control of spinal-cord patterning
J Jacob et al.
EMBO REPORTS (2003)
Structural basis for recruitment of glycogen synthase kinase 3β to the axin-APC scaffold complex
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EMBO JOURNAL (2003)
Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of frizzled
HC Wong et al.
MOLECULAR CELL (2003)
β-Catenin-mediated transactivation and cell -: cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells
AS Jaiswal et al.
ONCOGENE (2002)
Wnt/Wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear β-catenin-TCF complex
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CELL (2002)
Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism
CM Liu et al.
CELL (2002)
Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Physiological regulation of ß-catenin stability by Tcf3 and CK1ε
E Lee et al.
JOURNAL OF CELL BIOLOGY (2001)
Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism
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NATURE GENETICS (2001)
Crystal structure of a β-catenin/Tcf complex
TA Graham et al.
CELL (2000)
Pontin52 and Reptin52 function as antagonistic regulators of β-catenin signalling activity
A Bauer et al.
EMBO JOURNAL (2000)
Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling
WG Liu et al.
NATURE GENETICS (2000)
The APC tumour suppressor has a nuclear export function
R Rosin-Arbesfeld et al.
NATURE (2000)
Structural basis of the Axin-adenomatous polyposis coli interaction
KE Spink et al.
EMBO JOURNAL (2000)
The p300/CBP acetyltransferases function as transcriptional coactivators of β-catenin in vertebrates
A Hecht et al.
EMBO JOURNAL (2000)
The transcriptional coactivator CBP interacts with β-catenin to activate gene expression
KI Takemaru et al.
JOURNAL OF CELL BIOLOGY (2000)
Protein phosphatase 2A: a panoply of enzymes
DM Virshup
CURRENT OPINION IN CELL BIOLOGY (2000)
Protein phosphatase 2Cα dephosphorylates axin and activates LEF-1-dependent transcription
ET Strovel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
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NATURE GENETICS (2000)
Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer
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EUROPEAN JOURNAL OF CANCER (2000)
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