4.7 Article

Convalescent plasma is of limited clinical benefit in critically ill patients with coronavirus disease-2019: a cohort study

Journal

JOURNAL OF TRANSLATIONAL MEDICINE
Volume 19, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s12967-021-03028-5

Keywords

Convalescent plasma; Coronavirus; Coronavirus disease-2019; Mortality; SARS-CoV-2

Funding

  1. National Natural Science Grant of China [31571407]
  2. Special Fund to Fight COVID-19 in Guangzhou Women and Children's Medical Center [5001-4001010]
  3. Grant for Clinical Research in Xi'an Jiaotong University [XJTU1AF-CRF-2016-023]

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This study analyzed the characteristics and outcomes of patients with or without convalescent plasma (CP) transfusion for coronavirus disease-2019. The results showed that while CP transfusion was clinically safe, it did not provide significant clinical benefits for critically ill patients with more comorbidities at the late stage of disease during a 28-day observation.
Background: Recently, convalescent plasma (CP) transfusion was employed for severe or critically ill patients with coronavirus disease-2019. However, the benefits of CP for patients with different conditions are still in debate. To contribute clinical evidence of CP on critically ill patients, we analyze the characteristics and outcomes of patients with or without CP transfusion. Methods: In this cohort study, 14 patients received CP transfusion based on the standard treatments, whereas the other 10 patients received standard treatments as control. Clinical characteristics and outcomes were analyzed. The cumulative survival rate was calculated by Kaplan-Meier survival analysis. Results: Data analysis was performed on 24 patients (male/female: 15/9) with a median age of 64.0 (44.5-74.5) years. Transient fever was reported in one patient. The cumulative mortality was 21% (3/14) in patients receiving CP transfusion during a 28-day observation, whereas one dead case (1/10) was reported in the control group. No significant difference was detected between groups in 28-day mortality (P = 0.615) and radiological alleviation of lung lesions (P = 0.085). Conclusion: In our current study, CP transfusion was clinically safe based on the safety profile; however, the clinical benefit was not significant in critically ill patients with more comorbidities at the late stage of disease during a 28-day observation.

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