Journal
POLYMERS
Volume 13, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/polym13162813
Keywords
chitosan; carboxymethyl cellulose; clarithromycin; interpolymer complexes; hydrogel; polyelectrolyte complexes; drug delivery
Categories
Funding
- Ministerio de Ciencia e Innovacion [MICINU] [RTI2018-093940-B-100]
- UCM [910939]
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This study investigated the use of different proportions of cationic chitosan and anionic carboxymethyl cellulose in developing polyelectrolyte complexes for sustained-release systems. The analysis confirmed that these complexes enhanced drug encapsulation and enabled prolonged drug release, with a transport mechanism controlled by Fickian diffusion.
This study investigated the combination of different proportions of cationic chitosan and anionic carboxymethyl cellulose (CMC) for the development of polyelectrolyte complexes to be used as a carrier in a sustained-release system. Analysis via scanning electron microscopy (SEM) Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) confirmed ionic interactions occur between the chitosan and carboxymethyl cellulose chains, which increases drug entrapment. The results of the dissolution study in acetate buffer (pH 4.2) showed significant increases in the kinetic profiles of clarithromycin for low proportions of chitosan/carboxymethyl cellulose tablets, while the tablets containing only chitosan had high relaxation of chitosan chains and disintegrated rapidly. The Korsmeyer-Peppas kinetic model for the different interpolymer complexes demonstrated that the clarithromycin transport mechanism was controlled by Fickian diffusion. These results suggest that the matrix tablets with different proportions of chitosan/carboxymethyl cellulose enhanced the ionic interaction and enabled the prolonged release of clarithromycin.
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