Journal
THERANOSTICS
Volume 11, Issue 15, Pages 7589-7599Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.61259
Keywords
biomimetic; radiosensitization; brachytherapy; colon cancer; hypoxia
Categories
Funding
- National Natural Science Foundation of China [12005158]
- Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund [znpt2019045]
- foundation of Guizhou Provincial Education Department [KY (2020)003]
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This study developed a biomimetic nanotheranostic platform to enhance the efficacy of interstitial brachytherapy (BT) for cancer. By utilizing the targeting capabilities of nanoparticles, the treatment successfully evaded immune clearance and specifically accumulated in tumor tissues, resulting in improved therapeutic outcomes.
Rational: Interstitial brachytherapy (BT) is a promising radiation therapy for cancer; however, the efficacy of BT is limited by tumor radioresistance. Recent advances in materials science and nanotechnology have offered many new opportunities for BT. Methods: In this work, we developed a biomimetic nanotheranostic platform for enhanced BT. Core-shell Au@AuPd nanospheres (CANS) were synthesized and then encapsulated in platelet (PLT)-derived plasma membranes. Results: The resulting PLT/CANS nanoparticles efficiently evaded immune clearance and specifically accumulated in tumor tissues due to the targeting capabilities of the PLT membrane coating. Under endoscopic guidance, a BT needle was manipulated to deliver appropriate radiation doses to orthotopic colon tumors while sparing surrounding organs. Accumulated PLT/CANS enhanced the irradiation dose deposition in tumor tissue while alleviating tumor hypoxia by catalyzing endogenous H2O2 to produce O2. After treatment with PLT/CANS and BT, 100% of mice survived for 30 days. Conclusions: Our work presents a safe, robust, and efficient strategy for enhancing BT outcomes when adapted to treatment of intracavitary and unresectable tumors.
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