Journal
TURKISH JOURNAL OF MEDICAL SCIENCES
Volume 51, Issue 4, Pages 1960-1968Publisher
TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY
DOI: 10.3906/sag-2101-161
Keywords
Solid-organ transplant recipients; drug-resistant; bacteremia
Categories
Ask authors/readers for more resources
This study evaluated bacteremia due to XDR gram-negative pathogens among SOT recipients, finding that catheter-associated bacteremia and early-onset bacteremia are independent risk factors for mortality.
Background/aim: The aim of this study is to evaluate the distribution, sources, clinical features, and mortality rates of bacteremia due to evaluation of extensively drug-resistant (XDR) gram negative among solid-organ transplant (SOT) recipients. Materials and methods: A retrospective study of SOT recipients with bacteremia due to XDR gram-negative pathogens in 11 centers between 2016 and 2018 was conducted. Patients' records were evaluated. Results: Of 171 bacteremia that occurred in 164 SOT recipients, 93 (56.7%) were liver, 46 (28%) kidney, 14 (8.5%) heart, and 11 (6.7%) lung recipients. Bacteremia episodes were recorded in the first year in 63.7% of the patients (n = 109), early-onset bacteremia was recorded in 45% (n = 77) of the episodes. In multivariate analysis, catheter-associated bacteremia was an independent risk factor for 7-day mortality (p = 0.037), and early-onset bacteremia was found as an independent risk factor for 30-day mortality (p = 0.017). Conclusion: Difficult-to-treat infections due to XDR bacteria in SOT recipients shadow the success of transplantation. Central venous catheters seem to be the main risk factor. Judicious use of medical devices is of pivotal importance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available