Journal
ANALYTICAL METHODS
Volume 13, Issue 37, Pages 4238-4245Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ay01206a
Keywords
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Funding
- National Natural Science Foundation of China [22075095]
- Key Laboratory Construction Project of Jilin Province [20190901002JC]
- Natural Science Foundation of Jilin Province [20200201169JC]
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A fluorescent probe for viscosity detection was designed and synthesized in this study, using 1,4-dihydropyridine and indole iodide salt as the fluorophore and recognition group, with advantages including deep-red emission, low cytotoxicity, and targeting mitochondria, showing good clinical application potential.
Cell viscosity is related to some diseases, such as diabetes, atherosclerosis, and Alzheimer's disease. These diseases can cause abnormal viscosity of the cell mitochondrial matrix. 1,4-Dihydropyridine (DHP) is an important organic compound with biological activity and is widely used in drug research. However, there are few studies on its optical properties, especially in the design of viscous fluorescent probes. In this study, a fluorescent probe for viscosity detection using 1,4-dihydropyridine as the fluorophore and indole iodide salt as the recognition group was designed and synthesized. The probe has the advantages of a deep-red emission, low cytotoxicity, good biocompatibility and excellent anti-interference ability. In addition, the probe also has the ability to target mitochondria and has been successfully applied to the detection of the viscosity response of HeLa cells and living mice, and has good clinical application potential.
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