Designed multifunctional ratiometric fluorescent probe for directly detecting fluoride ion/ dichromate and indirectly monitoring urea

UiO-66-NH2@eosin Y composite was obtained by confining eosin Y (EY) into the cavities of Zr-MOF and could emit two fluorescence peaks at 453 and 543 nm at an excitation wavelength of 355 nm. This multi-responsive and multifunctional ratiometric fluorescent nanoprobe not only enable directly distinct detection of F-/Cr2O7 2 with ultra-high selectivity and sensitivity, but also could indirectly monitor the concentration of urea based on unique enzymatic hydrolysis reaction. The multifunctional probe was utilized for fluorescence labeling F-/Cr2O72-in sweat latent fingerprint through an environmentally friendly powder strategy and exhibited obvious luminescence visualization changes. Notably, the corresponding portable on-line test strips of probe for detection of F and Cr2O72-were made for monitoring the levels of F- and Cr2O72-. Furthermore, the probe was applied to evaluate the degrees of F-/Cr2O72-in HepG-2 cell and urea in serum with superior results,which indicate the potential application of the as-synthesized UiO-66-NH2@EY as multifunctional probe for the detection of F-, Cr2O7 2-and urea in biological samples. Finally, in order to extend the device-based applications of probe, an AND-OR coupled molecular logic gate was put on agenda. Superscript/Subscript Available

Automated summary

The UiO-66-NH2@eosin Y composite was prepared by confining eosin Y (EY) in the cavities of Zr-MOF, resulting in a multi-responsive and multifunctional ratiometric fluorescent nanoprobe. This probe can directly detect F-/Cr2O7 2, indirectly monitor the concentration of urea, and exhibit obvious luminescence visualization changes in sweat latent fingerprints through an environmentally friendly powder strategy.