Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2018, Issue 2, Pages 140-146Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201701279
Keywords
Asymmetric catalysis; Asymmetric synthesis; Cyclic imines; Dibenzoxazepines; Nitrogen heterocycles; Chiral amines
Categories
Funding
- MINECO (Gobierno de Espana) [CTQ2013-(47494-P)]
- Generalitat Valenciana
- MINECO
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The dibenzo[b,f][1,4]oxazepine scaffold is a privileged structure in medicinal chemistry that displays a wide variety of biological and pharmacological activities. However, catalytic asymmetric methodologies for the synthesis of chiral dibenzo[b,f][1,4]oxazepine derivatives are scarce in the literature. This microreview presents an overview of enantioselective reactions in which these cyclic seven-membered imines are used as electrophiles, including their substrate scope, limitations and application to the synthesis of related compounds.
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