Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2017, Issue 11, Pages 1552-1560Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201700048
Keywords
alpha-(Trifluoromethyl)imines; gamma-Addition reactions; Asymmetric catalysis; Phosphanes; Chirality
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Funding
- National Basic Research Program of China [(973)-2015CB856603]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- National Natural Science Foundation of China [20472096, 21372241, 21572052, 20672127, 21421091, 21372250, 21121062, 21302203, 20732008]
- Fundamental Research Funds for the Central Universities
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We have described the first asymmetric umpolung gamma-addition reaction of isatin-derived alpha-(trifluoromethyl)imines and allenoates. A chiral multifunctional phosphine catalyst derived from an amino acid promotes this reaction very well un-der mild conditions to give a series of enantiomerically enriched isatin-derived alpha-(trifluoromethyl)imine derivatives in high yields and with moderate to good enantioselectivities.
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