Kappa Deleting Recombination Excision Circle (KREC) Immunoglobulin Gene Rearrangement Mechamism and Importance in Transplants

Kappa deleting recombination excision circle (KREC) is a molecular structure that occurs as a result of the specific response of B lyinphocytes to protect the immune system against a wide variety of antigens and is considered to be an indicator of early immune response, especially in immunodeficiency disease patients. KREC can be measured with molecular analysis methods to show B cell output from the bone marrow and there has been an increase in clinical studies on the subject recently. This review is focused on explaining the mechanism of KREC occurrence, the importance of KREC measurement and its role in the treatment of diseases.

Automated summary

KREC is a molecular structure that occurs in response to B lymphocytes, protecting the immune system against various antigens and serving as an indicator of early immune response, especially in immunodeficiency patients. It can be measured through molecular analysis to show B cell output from the bone marrow and has been increasingly studied in clinical settings. The mechanism of KREC occurrence, importance of KREC measurement, and its role in disease treatment are the main focus of this review.