New insights of structural activity relationship of curcumin and correlating their efficacy in anticancer studies with some other similar molecules

Recently, Cancer is the widespread category of different diseases in human beings, and its progress is linked with a number of factors such as estrogen level, diet, hereditary etc. Curcumin is a naturally occurring compound which appears to be significant clinical for applications in vitro as well as in vivo studies. Many of the research groups have been paying attention towards natural products for the development of anticancer drugs. Curcumin, Rosmarinic acid and Chalcone are the naturally occurring compounds, which are chemopreventive and chemotherapeutic. In present review the anticancer activity of curcumin and similar analogues in vitro has been discussed on the basis of inhibitory concentration (IC50). Also this data is compared with the inhibitory concentration of chalcone, its derivatives and rosmarinic acid.

Automated summary

Studies have shown that curcumin and its analogues have potential value in anti-cancer activity, attracting the attention of many researchers. Natural products such as curcumin, rosmarinic acid and chalcone have positive effects on cancer prevention and treatment.