Journal
NEUROIMAGE-CLINICAL
Volume 32, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2021.102810
Keywords
ABCD; fMRI; Imaging; Conduct problems; Antisocial behavior; Callous-unemotional; Punishment sensitivity
Categories
Funding
- National Institutes of Health
- National Institute on Drug Abuse [F31 DA047750]
- [K01 MH119216]
- [U01DA041022]
- [U01DA041025]
- [U01DA041028]
- [U01DA041048]
- [U01DA041089]
- [U01DA041093]
- [U01DA041106]
- [U01DA041117]
- [U01DA041120]
- [U01DA041134]
- [U01DA041148]
- [U01DA041156]
- [U01DA041174]
- [U24DA041123]
- [U24DA041147]
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This study examined neural sensitivity to loss anticipation and receipt among youth with DBD, finding no significant differences in brain activity across groups. The results suggest that differences in punishment sensitivity among youth with DBD are unrelated to loss anticipation or receipt.
Etiological models highlight reduced punishment sensitivity as a core risk factor for disruptive behavior disorders (DBD) and callous-unemotional (CU) traits. The current study examined neural sensitivity to the anticipation and receipt of loss, one key aspect of punishment sensitivity, among youth with DBD, comparing those with and without CU traits. Data were obtained from the Adolescent Brain and Cognitive Development (ABCD)SM Study (N =11,874; Mage = 9.51; 48% female). Loss-related fMRI activity during the monetary incentive delay task was examined across 16 empirically-derived a priori brain regions (e.g., striatum, amygdala, insula, anterior cingulate cortex, medial prefrontal cortex) and compared across the following groups: (1) typically developing (n = 693); (2) DBD (n = 995), subdivided into those (3) with CU traits (DBD + CU, n = 198), and (4) without CU traits (DBD-only, n = 276). Latent variable modeling was also employed to examine network-level activity. There were no significant between-group differences in brain activity to loss anticipation or receipt. Null findings were confirmed with and without covariates, using alternative grouping approaches, and in dimensional models. Network-level analyses also demonstrated comparable activity across groups during loss anticipation and receipt. Findings suggest that differences in punishment sensitivity among youth with DBD are unrelated to loss anticipation or receipt. More precise characterizations of other aspects punishment sensitivity are needed to understand risk for DBD and CU traits.
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