Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 77, Pages 9862-9865Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc03733a
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Funding
- National Natural Science Foundation of China [21864013]
- Science Foundation for Excellent Young Scholars of Jiangxi Province [20202ZDB01003]
- Natural Science Foundation of Jiangxi Province [20202BAB203008]
- Open Project Program of the Key Laboratory of Functional Small Organic Molecules, Ministry of Education, Jiangxi Normal University [KLFSKF-201917]
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A simple thermal aptasensing platform was developed for sensitive detection of organophosphate pesticides, specifically using malathion as a model target. The platform utilizes the efficient self-heating reaction of a warming pad with a switchable target responsive enzyme-encapsulated three-dimensional DNA hydrogel, with a portable thermometer as the signal readout. This strategy demonstrates excellent specificity, reproducibility, and stability, and has potential for extension to monitor other molecules using different aptamer sequences.
A simple thermal aptasensing platform was devised for the sensitive detection of organophosphate pesticides (using malathion as a model target) based on the efficient self-heating reaction of a warming pad with a switchable target responsive enzyme-encapsulated three-dimensional (3D) DNA hydrogel using a portable thermometer as a signal readout in this work. The existence of the target malathion would open the catalase-3D network and lots of catalase was released from the hydrogel, which could efficiently convert H2O2 to an O-2 molecule. The product O-2 is the critical condition for the self-heating of the warming pad. Thereafter, the temperature was enhanced with the increasing amount of O-2. The strategy displays outstanding specificity, reproducibility and stability. Moreover, this method can be easily extended to monitor other molecules using different aptamer sequences in practical applications.
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