Journal
AGING-US
Volume 13, Issue 16, Pages 19954-19962Publisher
IMPACT JOURNALS LLC
Keywords
mortality; COVID-19; SARS-CoV-2; pediatrics; aging
Categories
Funding
- NIH
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Research shows that COVID-19 mortality rate in children follows a U-shaped curve, reaching its minimum at ages 3-10 and then increasing with age. Childhood mortality rates from COVID-19 are considerably lower than from other diseases, indicating that children are better protected at youngest ages.
Children are known to be better protected from COVID-19 than adults, but their susceptibility patterns and the risk relative to other diseases are insufficiently defined. Here, we found that the COVID-19 mortality rate is U-shaped in childhood: it initially decreases, reaching the minimum at the ages 3-10 years, and then increases throughout life. All-cause mortality and mortality from other diseases, such as pneumonia and influenza, show a similar pattern; however, childhood mortality rates from COVID-19 are considerably lower than from other diseases, with the best relative protection achieved at the youngest ages. Consistent with this, the fraction of COVID-19 deaths among all deaths increases as a function of age throughout childhood and the entire life. We discuss implications of the elevated postnatal COVID-19 risk and lower childhood COVID-19 mortality compared to other diseases.
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