Journal
CELL TRANSPLANTATION
Volume 30, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/09636897211034464
Keywords
bone marrow mesenchymal stem cells; cerebrospinal fluid; cell-based therapy; intrathecal route; matrix metalloproteinase
Funding
- School of Veterinary Medicine and Animal Science, Sao Paulo State University (FMVZ/UNESP), Botucatu, Brazil.
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The study demonstrates that intrathecal transplantation of BM-MSCs in dogs provides a safe, easy, and minimally invasive route for the use of cell-based therapeutics in central nervous system diseases.
The route used in the transplantation of mesenchymal stem cells (MSCs) can directly affect the treatment success. The transplantation of MSCs via the intrathecal (IT) route can be an important therapeutic strategy for neurological disorders. The objective of this study was to evaluate the safety and feasibility of the IT transplantation of autologous (Auto-MSCs) and allogeneic (Allo-MSCs) bone marrow mesenchymal stem cells (BM-MSCs) in healthy dogs. Based on neurodisability score, cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI), no significant differences from the control group were observed on day 1 or day 5 after IT Auto- or Allo-MSCs transplantation (P > 0.05). In addition, analysis of matrix metalloproteinase (MMP)-2 and MMP-9 expression in the CSF revealed no significant differences (P > 0.05) at 5 days after IT transplantation in the Auto- or Allo-MSCs group when compared to the control. Intrathecal transplantation of BM-MSCs in dogs provides a safe, easy and minimally invasive route for the use of cell-based therapeutics in central nervous system diseases.
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