Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 45, Issue 7, Pages 964-974Publisher
WILEY
DOI: 10.1111/ejn.13538
Keywords
anterior intraparietal sulcus; body ownership; paired-pulse TMS; primary motor cortex; sensory-motor mismatch
Categories
Funding
- Lundbeck Foundation [R59-A5399]
- Novo Nordisk Foundation [NNF14OC0011413]
- Lundbeck Foundation [R186-2015-2138] Funding Source: researchfish
- Novo Nordisk Fonden [NNF14OC0011413] Funding Source: researchfish
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Accumulating evidence suggests that parieto-frontal connections play a role in adjusting body ownership during the Rubber Hand Illusion (RHI). Using a motor version of the rubber hand illusion paradigm, we applied single-site and dual-site transcranial magnetic stimulation (TMS) to investigate cortico-spinal and parietal-frontal connectivity during perceived rubber hand ownership. Healthy volunteers received a conditioning TMS pulse over left anterior intraparietal sulcus (aIPS) and a test TMS pulse over left primary motor cortex (M1). Motor Evoked Potentials (MEPs) were recorded at rest and during three RHI conditions: (i) agency and ownership, (ii) agency but no ownership and (iii) neither agency nor ownership. Parietal-motor communication differed among experimental conditions. The induction of action ownership was associated with an inhibitory parietal-to-motor connectivity, which was comparable to the aIPS-to-M1 inhibition present at rest. This aIPS-to-M1 inhibition disappeared during movement conditions not inducing ownership. Cortico-spinal excitability was not significantly modulated during the motor RHI as indicated by the task-constant MEP amplitude elicited by the M1 test pulse alone. Our results indicate that the perceived ownership over the rubber hand is associated with normal parietal-motor communication. This communication is disturbed if the sensorimotor conflict between one's own hand and the rubber hand is not resolved.
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