Journal
EUROPEAN JOURNAL OF NEUROLOGY
Volume 25, Issue 1, Pages 59-70Publisher
WILEY
DOI: 10.1111/ene.13439
Keywords
Alzheimer's disease; epidemiology; genetics; pathogenesis; pathology; treatment
Categories
Funding
- NIHR Queen Square Dementia Biomedical Research Unit
- NIHR UCL/H Biomedical Research Centre
- Wolfson Foundation
- EPSRC [EP/J020990/1]
- MRC [MR/L023784/1]
- ARUK [ARUK-Network 2012-6-ICE, ARUK-PG2017-1946]
- Brain Research Trust [UCC14191]
- European Union's Horizon 2020 research and innovation programme [666992]
- Anonymous Foundation
- Cytox from Innovate UK
- UK Department of Business
- Engineering and Physical Sciences Research Council [EP/J020990/1] Funding Source: researchfish
- Medical Research Council [MR/L023784/1] Funding Source: researchfish
- MRC [MR/L023784/2] Funding Source: UKRI
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Alzheimer's disease, the commonest cause of dementia, is a growing global health concern with huge implications for individuals and society. In this review, current understanding of the epidemiology, genetics, pathology and pathogenesis of Alzheimer's disease is outlined, before its clinical presentation and current treatment strategies are discussed. Finally, the review discusses how our enhanced understanding of Alzheimer pathogenesis, including the recognition of a protracted preclinical phase, is informing new therapeutic strategies with the aim of moving from treatment to prevention.
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