Journal
EUROPEAN JOURNAL OF NEUROLOGY
Volume 24, Issue 5, Pages 751-754Publisher
WILEY
DOI: 10.1111/ene.13286
Keywords
dorsolateral prefrontal cortex; Parkinson's disease; pathological gambling; transcranial direct current stimulation
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Funding
- AIRAlzh Onlus-COOP Italia
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Background and purposePerformance on gambling tasks in Parkinson's disease (PD) is of particular interest, as pathological gambling is often associated with dopamine replacement therapy in these patients. We aimed to evaluate the effects of transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex (DLPFC) in modulating gambling behaviour in PD. MethodsWe assessed the effects of cathodal tDCS over the right DLPFC during the Iowa Gambling Task in 20 patients with PD, compared with sham stimulation. We then conducted a second experimental design, assessing the effects of anodal tDCS over the right DLPFC. ResultsWe observed that cathodal tDCS over the right DLPFC increased Iowa Gambling Task scores compared with sham stimulation. In the second experimental design, we did not find significant differences between anodal and sham tDCS. ConclusionsCathodal tDCS over the right DLPFC possibly reduces the pathological overdrive in frontostriatal networks in patients with PD on dopaminergic medication, thus modulating impulsive and risky decision-making.
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