Journal
JOURNAL OF CANCER
Volume 12, Issue 16, Pages 5035-5045Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.59391
Keywords
exosomes; tumor-derived exosomes; biomarkers; cancer detection
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Funding
- Zhejiang Provincial Natural Science Foundation of China [LY20H160008]
- Department of Health of Zhejiang Province [2019329972]
- National Natural Science Foundation of China [82074052]
- Hangzhou Social Development of Scientific Research projects [20191203B17]
- Key projects of National Natural Science Foundation of China [81730108]
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Exosomes, as potential cancer biomarkers, have a variety of endogeneous cargos reflecting tumor cell information, making them valuable for cancer diagnosis and treatment. Various sensitive methods have been developed to isolate and detect exosomes, suggesting promising applications in the field of cancer research.
Exosomes carry genetic information originating from their parental cells, raising their possibility as novel noninvasive biomarkers for cancer. Tumor-derived exosomes (TEXs) have a variety of endogenous cargos that reflect the pathophysiology status and information of tumor cells. TEXs are increasingly being recognized as potential biomarkers for cancer diagnosis prognosis, and monitoring. It is important to develop a variety of sensitive methods, including probes and biomaterials to isolate exosomes. A variety of approaches for detecting exosomes have been established. By combining exosome DNA and RNA sequencing tools, exosome proteomics analysis and immunoassay technology, it is expected that exosomes will gain widespread use in the diagnosis and treatment of cancer.
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