Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 9, Issue 39, Pages 8185-8201Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb01446c
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Funding
- China Postdoctoral Science Foundation [2019M663505]
- Sichuan University Postdoctoral Interdisciplinary Innovation Fund
- Technology Innovation Project of Chengdu Science and Technology [2020-YF05-00059-SN]
- Science and technology research project on novel coronavirus pneumonia outbreak, West China Hospital, Sichuan University [HX-2019-nCoV069]
- 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University [ZYJC18035]
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This review outlines the role of nanomaterials in preventing and treating the cytokine storm of COVID-19, including direct inhibition of cytokine release and delivery of anti-inflammatory drugs. It also highlights the important role of nanomaterials in diagnostics with improved sensitivity and specificity.
During the global outbreak of coronavirus disease 2019 (COVID-19), a hyperinflammatory state called the cytokine storm was recognized as a major contributor to multiple organ failure and mortality. However, to date, the diagnosis and treatment of the cytokine storm remain major challenges for the clinical prognosis of COVID-19. In this review, we outline various nanomaterial-based strategies for preventing the COVID-19 cytokine storm. We highlight the contribution of nanomaterials to directly inhibit cytokine release. We then discuss how nanomaterials can be used to deliver anti-inflammatory drugs to calm the cytokine storm. Nanomaterials also play crucial roles in diagnostics. Nanomaterial-based biosensors with improved sensitivity and specificity can be used to detect cytokines. In summary, emerging nanomaterials offer platforms and tools for the detection and treatment of the COVID-19 cytokine storm and future pandemic.
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