Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 22, Pages 6452-6468Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo00952d
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- DRDO [ARMREB/STE/2018/210]
- UGC
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This review summarizes the progress made in the field of deoxyfluorination for the construction of biologically active molecules from 2011 to 2021. The development of novel reagents has enabled new mechanistic approaches to achieve organic transformations. The fusion of fluorine in drug molecules remains an important research area due to its presence in numerous pharmaceutical active ingredients.
The fusion of fluorine in drug molecules through different fluorinating reagents remains a cornerstone in pharmaceutical chemistry. Progress in the field of deoxyfluorination through the development of novel reagents has enabled new mechanistic approaches to achieve organic transformations. Methodologies for the incorporation of fluorine into a complex molecule continue to be an important area of research because of the presence of fluorine in a plethora of pharmaceutical active ingredients. In this review, we have summarized the 2011-2021 progress made in the area of deoxyfluorination for the construction of biologically active molecules. The synthetic strategies described in this review provided diversely substituted fluorinated molecules and a few of them have profound pharmacological activity.
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