Journal
NANOSCALE
Volume 13, Issue 37, Pages 15569-15575Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nr04227k
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Funding
- National Key Research and Development Program of China [2017YFA0205301]
- National Natural Science Foundation of China [82073380, 81921002, 8202010801]
- National Postdoctoral Program for Innovative Talents [BX20190205]
- China Postdoctoral Science Foundation [2020M671130]
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The NIR-II nanoprobe with AIE properties shows great potential for precise clinical diagnosis and treatment of cancer, with uniform size, high bio-identical capacity, metabolizable in vivo, and ideal photothermal therapeutic effects in tumor tissues.
Near-infrared two-zone (NIR-II) fluorescence imaging has attracted attention as a non-invasive imaging technology that provides centimeter-level depth and micron-level resolution. However, producing a NIR-II fluorescent nanoprobe with uniform size, high bio-identical capacity, and fluorescence intensity, while being metabolizable in vivo, remains a challenge. We first produce a hydrophobic NIR-II fluorescent molecule with AIE properties, and subject it to ultrasonic and extrusion treatments to generate a DSPE-PEG-encapsulated NIR-II nanoprobe with an ultra-homogeneous particle size. The current study based on in vitro and mouse tumor-bearing model-based experiments indicate that cancer cells could efficiently take up this nanoprobe, which aggregates in tumor tissues, is susceptible to metabolization, and enables ideal photothermal therapeutic effects. Thus, this NIR-II nanoprobe with AIE properties shows great potential for precise clinical diagnosis and treatment of cancer.
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