4.6 Article

A ratiometric electrochemical microsensor for monitoring chloride ions in vivo

Journal

ANALYST
Volume 146, Issue 20, Pages 6202-6210

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1an01370j

Keywords

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Funding

  1. National Natural Science Foundation of China [52073087]
  2. Natural Science Foundation of Hunan Province [2021JJ30238]
  3. Education Department of Hunan Province [20B221]

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A ratiometric electrochemical microsensor (REM) was developed for in vivo measurement of cerebral Cl- by utilizing uniform Ag nanoparticles and methylene blue to achieve high sensitivity, selectivity, stability, reproducibility, and anti-biofouling.
Chloride ion (Cl-), the most common anion in animal brain, has been verified to play a vital role in maintaining normal physiological processes. Thus, development of a reliable platform to determine Cl- is of great significance for brain research involving Cl-. In this work, a ratiometric electrochemical microsensor (REM) for the in vivo measurement of cerebral Cl- was designed. To prepare REM, uniform Ag nanoparticles (Ag NPs) with nano-level sizes were synthesized via an adsorption-reduction process, which served as selective recognition elements for Cl- determination, while methylene blue (MB) was absorbed and acted as an inner reference unit to avoid the environmental interference of complicated brain systems. As a result, this developed REM exhibited high sensitivity and selectivity, as well as good stability, reproducibility and anti-biofouling. This reliable approach was established to monitor Cl- in mouse brain.

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