Journal
ACS MATERIALS LETTERS
Volume 3, Issue 9, Pages 1284-1290Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmaterialslett.1c00329
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Funding
- Singapore National Research Foundation [R279-000-483-281]
- NUS [R279-000-482-133]
- Science and Technology Key Project of Shenzhen [JCYJ20200109114612308, JCYJ20190812163614809]
- National Natural Science Foundation of China [91859117, 81771906, 81971638]
- Shenzhen Key Laboratory of Ultrasound Imaging and Therapy [ZDSYS201802061806314]
- CAS Key Laboratory of Health Informatics [2011DP173015]
- Shenzhen Double Chain Grant [[2018]256]
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The study developed a lipid-decorated molecular photoacoustic contrast agent TFML, which effectively labeled live neutrophils for targeted brain tumor imaging in mice glioblastoma multiforme detection. This approach presents a promising prospect for neutrophil-based nanotherapeutics research.
The delivery of imaging agents to brain tumor sites has been a longstanding hindrance, because of the presence of blood-brain barriers (BBB) and the complex brain tumor microenvironment. The living cell-based delivery system has shown tantalizing prospects for therapeutic applications targeting oncological diseases. Herein, we design a lipid- decorated molecular photoacoustic contrast agent TFML, which can effectively label harvested live neutrophils without affecting the activation and transmigration functions. After labeling neutrophils with TFML probes, TFML-labeled neutrophil (TFML-NE) was adoptively transferred into the recipient body and demonstrated strong PA signals, good brain tumor-targeting capability, and was applied for mice glioblastoma multiforme (GBM) detection. The successful development of TFML probes for neutrophil labeling and brain tumor targeting PAI presents a promising prospect for neutrophil-based nanotherapeutics studies.
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