4.7 Review

Recyclable fluorous cinchona organocatalysts for asymmetric synthesis of biologically interesting compounds

Journal

CHEMICAL COMMUNICATIONS
Volume 57, Issue 79, Pages 10116-10124

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc03722f

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Funding

  1. Natural Science Foundation of Zhejiang Province [LQ19B020005]

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Organocatalysis offers unique activation modes, mild reaction conditions, and good catalyst adaptability, making it more efficient with the integration of green techniques. This article focuses on recyclable cinchona alkaloid-catalyzed reactions in the asymmetric synthesis of functionalized compounds of biological interest.
Organocatalysis has unique modes of activation, mild reaction conditions, and good catalyst structural amenability. The integration of green techniques such as catalyst recovery and one-pot reactions makes organocatalysis more efficient and attractive. Presented in this article are the recyclable cinchona alkaloid-catalyzed reactions including fluorination and Michael addition-initiated cascade reactions in asymmetric synthesis of functionalized compounds of biological interest.

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