Journal
SIGNAL TRANSDUCTION AND TARGETED THERAPY
Volume 6, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41392-021-00749-3
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Funding
- National Natural Science Foundation of China [31970839]
- National Key R&D Program of China [1316203]
- Independent Innovation Research Fund of Huazhong University of Science and Technology [2020kfyXGYJ017]
- HUST Academic Frontier Youth Team [2018QYTD10]
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SARS-CoV-2 infection causes changes in the immune phenotype of B cells in recovered COVID-19 patients, with reduced CD19 expression and disrupted immune regulation, providing a new target for treating COVID-19.
The SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients. In our study, we have characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation, but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation. However, the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation. Interestingly, we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients. Moreover, the BCR signaling and early B-cell response were disrupted upon BCR stimulation. Mechanistically, we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism. In conclusion, we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism, which may provide a new intervention target to cure COVID-19.
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