Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 21, Pages 6026-6031Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo01104a
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Funding
- Dahlem Research School
- Studienstiftung des deutschen Volkes
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [387284271 - SFB 1349]
- Fonds der Chemischen Industrie (FCI, Sachkostenzuschuss)
- DFG
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The benzothiazolium salt BT-SeCF2H serves as an efficient nucleophilic reagent for transferring difluoromethylselenyl groups onto organic molecules, allowing for the synthesis of valuable fluorinated compounds through deoxygenative reactions.
The benzothiazolium salt BT-SeCF2H is introduced as an efficient nucleophilic reagent for transferring difluoromethylselenyl groups onto organic molecules. SeCF2H-Containing selenoesters could be prepared upon deoxygenative substitution of readily available carboxylic acids, while silver catalysis allowed for efficient formation of (difluoromethyl)selenoethers, including the established electrophilic reagent BnSeCF2H, directly from simple alcohols. To the best of our knowledge, these deoxygenative reactions represent the first reported nucleophilic difluoromethylselenylation processes and thus open up new approaches to prepare valuable fluorinated compounds.
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