Journal
TOXICOLOGY RESEARCH
Volume 10, Issue 4, Pages 850-855Publisher
OXFORD UNIV PRESS
DOI: 10.1093/toxres/tfab068
Keywords
lactate; blood ammonia; biomarkers; mushroom poisoning; liver failure
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This study retrospectively analyzed patients with acute mushroom poisoning and liver damage, showing that lactate and blood ammonia levels at admission can predict the prognosis of patients.
The diagnosis of liver damage induced by mushroom poisoning is still challenging. This study aims to screen the early biological indexes that could predict acute mushroom poisoning with liver damage. The patients with acute mushroom poisoning and liver damage admitted to The First Affiliated Hospital of Dalian Medical University,China from July 2007 to August 2017 were analyzed retrospectively. A total of 66 patients were enrolled in this study, with 44 and 22 patients in the liver injury group and liver failure group, respectively. Ten patients in the liver failure group died, with a mortality of 45.5% in this group. Multivariable Cox regression showed that the blood ammonia (NH3) and lactic acid (Lac) at the time of admission were independently associated with the in-hospital time to death for patients with liver failure induced by mushroom poisoning. Lactate and blood ammonia at the time of admission could be used to predict the prognosis of patients with acute mushroom poisoning and liver failure.
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