Journal
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
Volume 13, Issue 1, Pages -Publisher
WILEY
DOI: 10.1002/dad2.12231
Keywords
Alzheimer's disease; apolipoprotein E; extracellular vesicles; oxidative stress
Categories
Funding
- Research Chair Louise & Andre Charron on Alzheimer's disease
- Armand-Frappier Fondation
- INAF
- MRIF
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The study examined the impact of APOE epsilon 4 on antioxidant apolipoproteins in circulating extracellular vesicles and plasma from individuals with cognitive impairment. Results showed that total antioxidant capacity and apolipoprotein D levels in cEVs could differentiate APOE epsilon 4 carriers from controls and predict their progression to AD after 5 years. These findings support the link between APOE epsilon 4 and AD onset, suggesting the potential use of cEVs oxidative signature in early AD diagnosis.
Introduction The substantial link between apolipoprotein E (APOE) epsilon 4 allele and oxidative stress may underlie enhanced Alzheimer's disease (AD) risk. Here, we studied the impact of APOE epsilon 4 on the level of apolipoproteins with antioxidant activities along with oxidative markers in circulating extracellular vesicles (cEVs) and plasma from cognitively impaired-not demented (CIND) individuals converted to AD (CIND-AD). Methods Apolipoproteins E, J, and D and antioxidant response markers were determined in cEVs and plasma using immunoblotting, electrochemical examination, and spectrofluorimetry. Results Total antioxidant capacity and apolipoprotein D levels in cEVs, as judged by regression analysis and cognitive performance correlations, allowed us to differentiate CIND APOE epsilon 4 carriers from controls and to predict their progression to AD 5 years later. Discussion Our findings support the pathological redox linkage between APOE epsilon 4 and AD onset and suggest the use of cEVs oxidative signature in early AD diagnosis.
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